CS-1226

Name	SJ-172550
Synonyms	CS-1226 SJ-172550 SJ 172550 MDMX Antagonist, SJ-172550 Methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester Acetic acid, 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester
CAS	431979-47-4

Molecular Formula	C22H21ClN2O5
Molar Mass	428.87
Density	1.27±0.1 g/cm3(Predicted)
Boling Point	560.8±60.0 °C(Predicted)
Solubility	10 mM in DMSO
Appearance	powder
Color	orange
pKa	-0.30±0.40(Predicted)
Storage Condition	Sealed in dry,2-8°C
In vitro study	The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates.

Last Update：2024-01-02 23:10:35

biological activity	SJ-172550 is a small molecule inhibitor of MDMX; the EC50 value of competitive binding to MDMX with wild-type p53 peptide is 5 μM.
target	IC50: 5 μM (MDMX)
in vitro study	The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates.

Last Update：2024-04-09 21:54:55

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Product Name: SJ-172550 Visit Supplier Webpage Request for quotation
CAS: 431979-47-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CS-1226

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