4547-02-8
BENZP-DINITRIDE-THIO-KETONE
CAS: 4547-02-8
Molecular Formula: C15H11ClN2S
4547-02-8 - Names and Identifiers
4547-02-8 - Physico-chemical Properties
| Molecular Formula | C15H11ClN2S |
| Molar Mass | 286.78 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 256-258?C (dec.) |
| Boling Point | 408.9±55.0 °C(Predicted) |
| pKa | 9.72±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Physical and Chemical Properties | Chemical properties of light yellow crystals. Melting point 248-250 °c (240-246 °c). |
| Use | Use an intermediate of the hypnotic agent alprazolam. |
4547-02-8 - Preparation Method of alprazolam intermediate benzodiazepine ketone
from Palm Bridge research
Application (patent) number:
CN201410332777.8
application date:
2014-07-14
Public/Announcement Number:
CN104130201B
Public/announcement date:
2016.06.01
applicant (patent):
Henan Yuchen Pharmaceutical Co., Ltd.
inventor:
Lu Ming , Guo Xuechao , brilliant stone , Ye Jidong , Yue Xiaokai
National and provincial code:
CN411023
Abstract:
The present invention relates to a kind of alprazolam intermediate benzodiazepine ketone preparation method, 2-amino-5-chloro-benzophenone (M
Last Update：2024-01-02 23:10:35
4547-02-8 - Preparation Method of alprazolam intermediate benzodiazepine ketone
Application (patent) number:
CN 201410332777
Public/Announcement Number:
CN104130201 A
applicant (patent):
Henan Yuchen Pharmaceutical Co., Ltd.
inventor:
Lu Ming , Guo Xuechao , brilliant stone , Ye Jidong , Yue Xiaokai
Abstract:
The present invention relates to a method for preparing an intermediate of alprazolam, using 2-amino-5-chloro-benzophenone (M2) as a raw material, through typical acylation reaction, cyclization reaction and sulfuration reaction, crude benzodiazepine ketone (HPLC content about 94%) was obtained. The crude product was recrystallized in a mixed solvent at room temperature to obtain a high quality product with HPLC content above 98.5%, melting point 238~242 ℃ (melting range below 3 ℃). In the present invention, the preparation method has fewer synthesis steps, mild process conditions, easy control of the refining method, high yield and high quality content, can control lower production costs and reduce environmental pollution, and is conducive to industrialization.
Last Update：2023-08-16 22:05:47
4547-02-8 - Synthesis of 7-chloro-5-phenylbenzodiazepine (pyridone) by phase transfer catalysis
from VIP Journal Professional Edition
Author:
Post , Liu Zhenzhong , Chen Hengchang
Abstract:
In this paper, 7-chloro-5-phenyl-benzodiazepines (Ⅰ) and P2S5 as raw materials, TBAB,TBAS catalyst, by Phase transfer catalysis (PTC) 7-chloro-5-ylphenyl-benzodiazepines were synthesized. The reaction has the advantages of high yield, mild conditions and easy operation.
Key words:
Last Update：2023-08-16 22:05:47
4547-02-8 - Synthesis of 7-chloro-5-phenylbenzodiazepine Thione by phase transfer catalysis
from VIP Journal Professional Edition
Author:
Abstract:
Abstract:
Key words:
phase transfer catalysis alprazolam intermediate
year:
1993
Last Update：2023-08-16 22:05:47
4547-02-8 - Reference Information
| Use | Intermediate of the hypnotic alprazolam. |
| Production method | Use 5-chloro-2-[(chloroacetyl) amino] benzophenone and hexamethylenetetramine to react under alkaline conditions to generate 7-Chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-one, which reacts with phosphorus pentasulfide under nitrogen protection, the product is made. |
Last Update：2024-04-09 19:05:07
Supplier List
Product Name: Alprazolam Impurity 26 Request for quotation
CAS: 4547-02-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 4547-02-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: BENZP-DINITRIDE-THIO-KETONE Request for quotation
CAS: 4547-02-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 4547-02-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
View History