BENZP-DINITRIDE-THIO-KETONE
BENZP-DINITRIDE-THIO-KETONE
CAS: 4547-02-8
Molecular Formula: C15H11ClN2S
BENZP-DINITRIDE-THIO-KETONE - Names and Identifiers
BENZP-DINITRIDE-THIO-KETONE - Physico-chemical Properties
| Molecular Formula | C15H11ClN2S |
| Molar Mass | 286.78 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 256-258?C (dec.) |
| Boling Point | 408.9±55.0 °C(Predicted) |
| pKa | 9.72±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Physical and Chemical Properties | Chemical properties of light yellow crystals. Melting point 248-250 °c (240-246 °c). |
| Use | Use an intermediate of the hypnotic agent alprazolam. |
BENZP-DINITRIDE-THIO-KETONE - Preparation Method of alprazolam intermediate benzodiazepine ketone
from Palm Bridge research
Application (patent) number:
CN201410332777.8
application date:
2014-07-14
Public/Announcement Number:
CN104130201B
Public/announcement date:
2016.06.01
applicant (patent):
Henan Yuchen Pharmaceutical Co., Ltd.
inventor:
Lu Ming , Guo Xuechao , brilliant stone , Ye Jidong , Yue Xiaokai
National and provincial code:
CN411023
Abstract:
The present invention relates to a kind of alprazolam intermediate benzodiazepine ketone preparation method, 2-amino-5-chloro-benzophenone (M
Last Update：2024-01-02 23:10:35
BENZP-DINITRIDE-THIO-KETONE - Preparation Method of alprazolam intermediate benzodiazepine ketone
Application (patent) number:
CN 201410332777
Public/Announcement Number:
CN104130201 A
applicant (patent):
Henan Yuchen Pharmaceutical Co., Ltd.
inventor:
Lu Ming , Guo Xuechao , brilliant stone , Ye Jidong , Yue Xiaokai
Abstract:
The present invention relates to a method for preparing an intermediate of alprazolam, using 2-amino-5-chloro-benzophenone (M2) as a raw material, through typical acylation reaction, cyclization reaction and sulfuration reaction, crude benzodiazepine ketone (HPLC content about 94%) was obtained. The crude product was recrystallized in a mixed solvent at room temperature to obtain a high quality product with HPLC content above 98.5%, melting point 238~242 ℃ (melting range below 3 ℃). In the present invention, the preparation method has fewer synthesis steps, mild process conditions, easy control of the refining method, high yield and high quality content, can control lower production costs and reduce environmental pollution, and is conducive to industrialization.
Last Update：2023-08-16 22:05:47
BENZP-DINITRIDE-THIO-KETONE - Synthesis of 7-chloro-5-phenylbenzodiazepine (pyridone) by phase transfer catalysis
from VIP Journal Professional Edition
Author:
Post , Liu Zhenzhong , Chen Hengchang
Abstract:
In this paper, 7-chloro-5-phenyl-benzodiazepines (Ⅰ) and P2S5 as raw materials, TBAB,TBAS catalyst, by Phase transfer catalysis (PTC) 7-chloro-5-ylphenyl-benzodiazepines were synthesized. The reaction has the advantages of high yield, mild conditions and easy operation.
Key words:
Last Update：2023-08-16 22:05:47
BENZP-DINITRIDE-THIO-KETONE - Synthesis of 7-chloro-5-phenylbenzodiazepine Thione by phase transfer catalysis
from VIP Journal Professional Edition
Author:
Abstract:
Abstract:
Key words:
phase transfer catalysis alprazolam intermediate
year:
1993
Last Update：2023-08-16 22:05:47
BENZP-DINITRIDE-THIO-KETONE - Reference Information
| Use | Intermediate of the hypnotic alprazolam. |
| Production method | Use 5-chloro-2-[(chloroacetyl) amino] benzophenone and hexamethylenetetramine to react under alkaline conditions to generate 7-Chloro-1, 3-dihydro-5-phenyl-2H-1, 4-benzodiazepine-2-one, which reacts with phosphorus pentasulfide under nitrogen protection, the product is made. |
Last Update：2024-04-09 19:05:07
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CAS: 4547-02-8
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View History
BENZP-DINITRIDE-THIO-KETONE
(1R,2S)-1 - [ [(1,1-二甲基乙氧基)羰基]氨基] - 2-乙烯基-环丙烷甲酸乙酯
三(三苯基磷)溴化亚铜
TRIPHENYLTIN HYDRIDE
Tetraamminepalladium(II) dichloride
beta-D-葡萄糖苷-3,4-二甲氧基苯酯
(R)-2-((叔丁氧羰基)氨基)-5-甲氧基-5-氧戊酸
Cyclohexaneethanamine Hydrochloride
15-HYDROXYPENTADECANOIC ACID
2-溴-6-硝基苯胺
(1R,2S)-1 - [ [(1,1-二甲基乙氧基)羰基]氨基] - 2-乙烯基-环丙烷甲酸乙酯
三(三苯基磷)溴化亚铜
TRIPHENYLTIN HYDRIDE
Tetraamminepalladium(II) dichloride
beta-D-葡萄糖苷-3,4-二甲氧基苯酯
(R)-2-((叔丁氧羰基)氨基)-5-甲氧基-5-氧戊酸
Cyclohexaneethanamine Hydrochloride
15-HYDROXYPENTADECANOIC ACID
2-溴-6-硝基苯胺