Name | diethoxymethane |
Synonyms | Ethylal diethoxymethane diethoxy-methan 3,5-dioxaheptene 1,1-Diethoxymethane (ethoxymethoxy)ethane 1-(Ethoxymethoxy)ethane formaldehyde diethyl acetal 1,1'-(methylenebis(oxy))bis-ethan 1,1'-[methylenebis(oxy)]bis-ethan 1,1'-[methylenebis(oxy)]bis-Ethane Ethane, 1,1'-[methylenebis(oxy)]bis- |
CAS | 462-95-3 |
EINECS | 207-330-6 |
InChI | InChI=1/C5H12O2/c1-3-6-5-7-4-2/h3-5H2,1-2H3 |
InChIKey | KLKFAASOGCDTDT-UHFFFAOYSA-N |
Molecular Formula | C5H12O2 |
Molar Mass | 104.15 |
Density | 0.831 g/mL at 25 °C (lit.) |
Melting Point | -66.5 °C |
Boling Point | 87-88 °C (lit.) |
Flash Point | 22°F |
Water Solubility | 4.2 G/100 ML |
Solubility | 91g/l |
Vapor Presure | 60 mm Hg ( 25 °C) |
Vapor Density | 3.6 (vs air) |
Appearance | Liquid |
Color | Clear colorless |
BRN | 1697253 |
Storage Condition | Store below +30°C. |
Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids. |
Explosive Limit | 1.5%(V) |
Refractive Index | n20/D 1.373(lit.) |
Physical and Chemical Properties | Colorless, clear and flammable liquid. melting point -66.5 ℃ boiling point 89 ℃ relative density 0.8319 refractive index 1.3748 soluble in acetone, water and benzene, highly soluble in ethanol, ether. |
Use | For organic synthesis, pharmaceutical industry |
Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S9 - Keep container in a well-ventilated place. S37/39 - Wear suitable gloves and eye/face protection S33 - Take precautionary measures against static discharges. |
UN IDs | UN 2373 3/PG 2 |
WGK Germany | 2 |
RTECS | PA8500000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
HS Code | 2911 00 00 |
Hazard Class | 3 |
Packing Group | II |
Toxicity | LD50 orally in Rabbit: 3536 mg/kg LD50 dermal Rat > 16600 mg/kg |
colorless clear flammable liquid. Boiling point 89 deg C. Melting Point -66.5 °c. Relative density (d20) 0.8319. Refractive index 3748. Soluble in acetone, water and benzene, easily soluble in ethanol, ether. The vapor forms an explosive mixture with air.
It can be produced by the aldol condensation reaction of formaldehyde with ethanol (used to be a by-product in the production of out-of-phase pharmaceutics).
can be used to produce synthetic resins, fragrances, paints, and can be used as solvents.
LogP | 0.84 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
introduction | diethoxymethane (DEM) has only begun to be commercialized in recent years, but it has attracted the attention of researchers due to its unique properties. Its typical properties are: suitable operating temperature range; low viscosity, easy to operate and handle; DEM has low solubility in water and water in DEM ; it forms binary azeotrope with water and ethanol respectively, which is beneficial to product purification; it is not mixed with water, easy to separate from water, and has good process economy; it has good stability, it is stable under strong alkali and weak acidic conditions such as hydroxide, sodium hydride, Grignard reagent, etc., and it is not easy to form peroxides. |
Uses | Used in organic synthesis and pharmaceutical industry Used in the synthesis of toluene formaldehyde resin, spices, and also used in the production of solvents and paints. |
production method | production of chloramphenicol by-products. p-nitroacetophenone is dissolved in chlorobenzene, stirred at 26-28 ℃ and bromine is added dropwise to brominate to obtain p-nitro-α-brominated acetophenone. Then urotropine was added and chlorobenzene was supplemented to prepare p-nitro-α-bromoacetophenone urotropine salt solution. The salt-forming solution is added to the hydrochloric acid solution of the 27%, and after the chlorobenzene is separated, ethanol and salt are added for hydrolysis reaction. It can also be prepared by the condensation reaction of formaldehyde and ethanol. |
category | flammable liquid |
toxicity classification | poisoning |
acute toxicity | oral-rabbit LD50: 2604 mg/kg |
flammability hazard characteristics | flammability in case of open flame, high temperature and oxidant; Combustion produces stimulating smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
fire extinguishing agent | dry powder, dry sand, dry stone powder, carbon dioxide, foam |
spontaneous combustion temperature | 346 °F |