476-70-0
Boldine
CAS: 476-70-0
Molecular Formula: C19H21NO4
476-70-0 - Names and Identifiers
476-70-0 - Physico-chemical Properties
| Molecular Formula | C19H21NO4 |
| Molar Mass | 327.37 |
| Density | 1.2223 (rough estimate) |
| Melting Point | 162-164°C |
| Boling Point | 465.27°C (rough estimate) |
| Solubility | Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly) |
| Appearance | neat |
| Color | Yellow to Dark Brown |
| Merck | 13,1316 |
| BRN | 94036 |
| pKa | 9.75±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5000 (estimate) |
| Physical and Chemical Properties | White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., is derived from the drug. |
476-70-0 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S1 - Keep locked up. S20 - When using, do not eat or drink. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | CE0750000 |
| HS Code | 29399990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
476-70-0 - Reference
| Reference Show more | Jiang Si, Wei, Zheng Zuoliang, Xu Fangfang et al. Simultaneous determination of four alkaloids in the prescription of Urbana-azaion by UPLC-QqQ-MS/MS [J]. Chinese Journal of Experimental prescription science 2019(17). |
476-70-0 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Boldine is an apomorphine isoquinoline alkaloid extracted from the root of Litsea cubeba, anti-inflammatory and cytoprotective effects. Boldine inhibits osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway, and can be used in rheumatoid arthritis studies. |
| Target | OPG/RANKL/RANK |
| Use | boldine has diuretic and anti-allergic effects in rats, and is used as a diuretic and anti-allergic agent. for content determination/identification/pharmacological experiments, etc |
Last Update：2024-04-10 22:29:15
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