5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Names and Identifiers

Name	5-Amino-3-Cyano-1-(2,6-Dichloro-4-TrifluoroMethylPhenyl)Pyrazole
Synonyms	FIPRONIL INTERMEDIATE 5-Amino-3-cyano-(2,6-dichloro-4-trifluoromethyl-phenyl)pyrazole 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole 5-Amino-3-Cyano-l-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole 5-Amino-3-cyano-1-(2,6-dichloro-4-trichloromethylphenyl)pyrazole 5-Amino-3-Cyano-1-(2,6-Dichloro-4-TrifluoroMethylPhenyl)Pyrazole 5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole 5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano pyrazole 5-AMINO-1-(2,6-DICHLORO-4-TRIFLUOROMETHYLPHENYL)-3-CYCANO PYRAZOLE 5-AMINO-3-CYANO-1-(2,6-DICHLORO-4-TRIFLUOROMETHYLPHENYL)-1H-PYRAZOLE 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3-pyrazolecarbonitrile 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile 5-AMINO-1-(2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOLE-3-CARBONITRILE
CAS	120068-79-3
InChI	InChI=1/C11H5Cl2F3N4/c12-7-1-5(11(14,15)16)2-8(13)10(7)20-9(18)3-6(4-17)19-20/h1-3H,18H2

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Physico-chemical Properties

Molecular Formula	C11H5Cl2F3N4
Molar Mass	321.09
Density	1.65±0.1 g/cm3(Predicted)
Melting Point	132-141 °C
Boling Point	433.0±45.0 °C(Predicted)
Flash Point	215.6°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	1.06E-07mmHg at 25°C
Appearance	Solid powder
Color	Light Yellow to Light Brown
pKa	-1.27±0.14(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.62
Physical and Chemical Properties	This product is pure white crystalline solid, industrial product is light yellow-brown solid, m.p.141 ~ 142 ℃, soluble in methanol, ethanol, acetone, dichloroethane and ethyl acetate.

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Reference Information

Use

5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl) pyrazole is abbreviated as pyrazole, which is an intermediate of the insecticide fipronil.

Production method

The preparation method is based on 2, 6-dichloro-4-trifluoromethylaniline as raw material, and diazotization reaction to obtain diazonium salt, The diazonium salt is condensed with ethyl dicyanopropionate and then ring-locked to obtain 5-amino -3-cyano -1-(2, 6-dichloro-4-trifluoromethylphenyl) pyrazole. Sulfuric acid and solvent were added to the reaction flask, sodium nitrite was added in batches under stirring, stirred for 30min after adding, 2, 6-dichloro-4-trifluoromethylaniline was added dropwise at 20~40 ℃, and stirred for 1h to obtain diazonium salt of 2, 6-dichloro-4-trifluoromethylaniline. Water and ethyl 2, 3-dicyanopropionate are added to the diazonium salt, stirred at room temperature for 2 hours, dichloromethane is added, after stirring evenly, the material is transferred to the separatory funnel, the water layer is separated, then dichloromethane is extracted, dichloromethane solution is combined, water is washed, then dilute alkali is washed to pH = 9, the reaction bottle is transferred, ammonia water is added, stirred at room temperature for 2 hours, then stratified, the water layer is extracted with dichloromethane, and the dichlorome, wash with water until neutral, and steam to remove dichloromethane to obtain the product.

Last Update：2024-04-09 02:00:06

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole

Jiangsu Pules Biotechnology Co.,Ltd.

Product Name: 5-Amino-3-Cyano-1-(2,6-Dichloro-4-TrifluoroMethylPhenyl)Pyrazole Request for quotation
CAS: 120068-79-3
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Shanghai Yuanye Bio-Technology Co., Ltd.

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Wuhan Boye Science And Technology Development Co., Ltd.

Product Name: 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Request for quotation
CAS: 120068-79-3
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Jiangsu Pules Biotechnology Co.,Ltd.

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Wechat: 18301782025

Wuhan Boye Science And Technology Development Co., Ltd.

Wechat: 15387090420

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5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole

5-Amino-3-Cyano-1-(2,6-Dichloro-4-TrifluoroMethylPhenyl)Pyrazole

CAS: 120068-79-3

Molecular Formula: C11H5Cl2F3N4

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Names and Identifiers

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Physico-chemical Properties

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Reference Information

Supplier List

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole Request for Quotation

5-Amino-3-Cyano-1-(2,6-Dichloro-4-TrifluoroMethylPhenyl)Pyrazole

CAS: 120068-79-3

Molecular Formula: C11H5Cl2F3N4

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Names and Identifiers

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Physico-chemical Properties

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole - Reference Information

Supplier List

5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyanopyrazole