51781-21-6
carteolol hydrochloride
CAS: 51781-21-6
Molecular Formula: C16H25ClN2O3
51781-21-6 - Names and Identifiers
| Name | carteolol hydrochloride |
| Synonyms | Carteol Cartrol OPC 1085 Caltidren Arteoptic NSC 300906 carteolol HCl Carteolol hydrochloride carteolol hydrochloride CARTEOLOL (HYDROCHLORIDE) dl-Carteolol hydrochloride 5-[3-[(tert-butyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2-quinolone monohydrochloride 5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone Hydrochloride 2(1H)-Quinolinone, 5-[3-[(1,1-Dimethylethyl)Amino]-2-Hydroxypropoxy]-3,4-Dihydro-, Monohydrochloride |
| CAS | 51781-21-6 |
| EINECS | 257-415-7 |
| InChI | InChI=1/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H |
51781-21-6 - Physico-chemical Properties
| Molecular Formula | C16H25ClN2O3 |
| Molar Mass | 328.83 |
| Melting Point | 278°C |
| Boling Point | 518.6°C at 760 mmHg |
| Flash Point | 267.4°C |
| Solubility | Soluble in water, sparingly soluble in methanol, slightly soluble in ethanol 96 per cent, practically insoluble in methylene chloride. |
| Vapor Presure | 1.4E-11mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,1866 |
| Storage Condition | Refrigerator |
51781-21-6 - Risk and Safety
| RTECS | VC8282000 |
| HS Code | 2933790002 |
| Toxicity | LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang) |
51781-21-6 - Standard
Authoritative Data Verified Data
This product is 5-[3-[(l,l-dimethylethyl) amino]-2-hydroxypropoxy]-3, 4-dihydro-2 (1H )-Quinolone hydrochloride. Based on the dry product, the content of C16H24N203 • HCl shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
51781-21-6 - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder.
- This product is dissolved in water, slightly soluble in methanol, very slightly soluble in ethanol, almost insoluble in ether; Very slightly soluble in glacial acetic acid.
Last Update：2022-01-01 14:21:35
51781-21-6 - Differential diagnosis
Authoritative Data Verified Data
- take about O.lg of this product, add 5ml of water to dissolve, and add 5 drops of chromium ammonium thiocyanate test solution to generate light red precipitate.
- take this product, add water to dissolve and dilute to make a solution containing 8ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is an absorption maximum at a wavelength of 215mn and 252nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 817).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:21:35
51781-21-6 - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, add 100ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 5.0~6.0.
clarity and color of solution
take 1.0g of this product and add 30ml of water to dissolve. The solution should be clear and colorless.
Related substances
take 0.20g of this product and add 10ml of methanol to dissolve it as a test solution. Take 2ml of precision measurement, put it in a 100ml measuring flask, dilute it to the scale with methanol, and shake it well, then 1ml was accurately measured, and the mixture was placed in a 10ml measuring flask, diluted to a scale with methanol, and shaken to obtain a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel GF254 thin layer plate, with chloroform-methanol-concentrated ammonia solution (50:20:1) for the development of the agent, expand, dry, set the UV light (254nm) under the inspection. Test solution such as impurity spots, compared with the control solution of the main spot, not deeper.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.5% (0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product l.Og, place in the crucible, Add 10ml of ethanol solution of magnesium nitrate (l-50), after ignition and combustion, slowly heat and ash, if there is Carbonized residue, wet with a small amount of nitric acid, and then heat Ash, cool, add 3ml hydrochloric acid, heat and dissolve on a water bath, transfer to the generating bottle with a small amount of water, add 1 drop of methyl orange indicator solution, and then neutralize with ammonia test solution or dilute hydrochloric acid as the test solution, inspection according to law (General Principles 0822 second law), with the standard arsenic solution 2m1 preparation standard arsenic control liquid, should meet the requirements (0.0002%).
Last Update：2022-01-01 14:21:36
51781-21-6 - Content determination
Authoritative Data Verified Data
take about 0.5g of this product, precision weighing, add glacial acetic acid 30ml, heat and dissolve in water bath, cool, add acetic anhydride 70ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 32.88mg of C16H24N203 • HCl.
Last Update：2022-01-01 14:21:36
51781-21-6 - Category
Authoritative Data Verified Data
B-adrenergic receptor blockers.
Last Update：2022-01-01 14:21:37
51781-21-6 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 14:21:37
51781-21-6 - Carteolol Hydrochloride Eye Drops
Authoritative Data Verified Data
- This product contains carteolol hydrochloride (C16H24N203 • HCl) should be 95.0% ~ 105.0% of the label amount.
- this product with an appropriate amount of benzalkonium chloride as bacteriostatic agent.
trait
This product is a clear colorless liquid.
identification
- This product is diluted with water to prepare a solution containing about 8ug of carteolol hydrochloride per 1 ml, and the solution is determined by UV-Vis spectrophotometry (General rule 0401), there is an absorption maximum at a wavelength of 215nm and 252nm.
- take this product and dilute it with water to make a solution containing about 5mg of carteolol hydrochloride per 1 ml as a test solution; Take an appropriate amount of carteolol hydrochloride reference substance, water was added to dissolve and diluted to prepare a solution containing about 5mg per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb 2 u1 of each of the above two solutions, respectively point on the same silica gel GF254 thin layer plate, with chloroform-methanol-concentrated ammonia solution (50:20:1) for the development of the agent, expand, dry, set the UV light (254nm) under the inspection. The position and color of the main spot of the test solution should be consistent with the main spot of the reference solution.
examination
- the pH value should be 6.2 to 7.2 (General 0631). Osmolality as determined by osmolality measurement (General 0632), the osmolality ratio should be 0.9 to 1.1.
- others shall comply with the relevant provisions under Ophthalmic Preparations (General rule 0105).
Content determination
precision: take an appropriate amount of this product and dilute it quantitatively with water to make a solution containing 16ug carteolol hydrochloride per lml, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 252mn; Take an appropriate amount of carteolol hydrochloride reference substance, weigh it precisely, dissolve it with water and dilute it to make a solution containing 16ug carteolol hydrochloride per 1 ml, and determine it by the same method, it is obtained by calculation.
category
Same as carteolol hydrochloride.
specification
(l )5ml:50mg (2)5ml:lOOmg
storage
sealed storage.
Last Update：2022-01-01 14:21:38
