Molecular Formula | C24H28O2 |
Molar Mass | 348.48 |
Density | 1.0932 (rough estimate) |
Melting Point | 242 °C |
Boling Point | 422.83°C (rough estimate) |
Solubility | chloroform/methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to light yellow |
Appearance | White solid |
pKa | 4.28±0.10(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.4480 (estimate) |
In vitro study | TTNPB binds to the nuclear retinoic acid receptor with high affinity, inhibiting the binding of [3H]tRA to mrra alpha, beta, and gamma with an IC50 of 3.8 nM, 4.0 nM, and 4.5 nM, respectively. After 72 hours of conditioned medium, TTNPB increased the transcriptional activity of murine RARs in JEG-3 cells with EC50 of 2.0 nM, 1.1 nM, and 0.8 nM for mrara, β, and γ, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle arrest. TTNPB caused a concentration-dependent decrease in ES-D3 cell differentiation. TTNPB binds to the nuclear retinoic acid receptor with high affinity, inhibiting [TTNPB increases the transcriptional activity of murine RARs in JEG-3 cells after 72 hours of conditioned media, the EC50 for gamma is 2.0 nM, 1.1 nM and 0.8 nM, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle arrest. TTNPB caused a concentration-dependent decrease in ES-D3 cell differentiation. |
In vivo study | TTNPB(0.25 mg/kg) caused growth inhibition in the MXT-HS and MXT-HI models by inducing apoptosis. TTNPB(0.25 mg/kg) caused growth inhibition in the MXT-HS and MXT-HI models by inducing apoptosis. |
Hazard Symbols | T - Toxic |
Risk Codes | R60 - May impair fertility R61 - May cause harm to the unborn child R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
WGK Germany | 3 |
RTECS | DH6834900 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.87 ml | 14.348 ml | 28.696 ml |
5 mM | 0.574 ml | 2.87 ml | 5.739 ml |
10 mM | 0.287 ml | 1.435 ml | 2.87 ml |
5 mM | 0.057 ml | 0.287 ml | 0.574 ml |
biological activity | TTNPB (Arotinoid Acid) is an effective RAR agonist that inhibits binding to [3H]tRA and acts on human RARα, β, and γ, IC50 are 5.1 nM, 4.5 nM, and 9.3 nM respectively. TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is an effective RAR agonist that inhibits binding to [3H]tRA and acts on human RARα, β, and γ, IC50 of 5.1 nM, 4.5 nM, and 9.3 nM, respectively. |
in vitro study | TTNPB binds to nuclear retinoic acid receptor with high affinity, inhibiting the binding of [3H]tRA to mRARα, β, and γ, and its IC50 is 3.8 nM, 4.0 nM, and 4.5 nM, respectively. After 72 h of conditioned medium, TTNPB increased the transcriptional activity of murine RARs in JEG-3 cells, with EC50 for mRARα, β, and γ being 2.0 nM, 1.1 nM, and 0.8 nM, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle arrest. TTNPB caused a concentration-dependent decrease in ES-D3 cell differentiation. TTNPB binds to nuclear retinoic acid receptors with high affinity and inhibits [After 72 hours of using conditioned medium, TTNPB increases the transcriptional activity of murine RARs in JEG-3 cells, and EC50 for mRARα, β, and γ are 2.0 nM, 1.1 nM, and 0.8 nM, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle arrest. TTNPB caused a concentration-dependent decrease in ES-D3 cell differentiation. |
in vivo studies | TTNPB(0.25 mg/kg) induces growth inhibition of MXT-HS and MXT-HI models by inducing apoptosis. TTNPB(0.25 mg/kg) induces growth inhibition of MXT-HS and MXT-HI models by inducing apoptosis. |
target | TargetValue RAR β (cell-free assay) 4.5 nM RAR α (cell-free assay) 5.1 nM RAR γ (cell-free assay) 9.3 nM |
Target | Value |
RARβ (cell-free assay) | 4.5 nM |
RARα (cell-free assay) | 5.1 nM |
RARγ (cell-free assay) | 9.3 nM |