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6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one

6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one

CAS: 179688-29-0

Molecular Formula: C14H18N2O5

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6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one - Names and Identifiers

Name 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one
Synonyms ERLOTINIBINT-F
Erlotinib iMpurity E
Erlotinib'S Intermediate
Erlotinib LactaM IMpurity
6,7-bis-Methoxyethoxy-quinazolin-4-one
6,7-Bis(2-Methoxyethoxy)Quinazolin-4(1H)-One
6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one
6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one
6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one
6,7-Bis-(2-Methoxyethoxy)Quinazolin-4(3H)-One
6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazolinone
6,7-Bis-(2-Methoxyethoxy)-Quinazolin-4(3H)-One
6,7-Bis(2-Methoxyethoxy)-3,4-Dihydroquinazolin-4-One
Methyl Ester, 2-Amino-4,5-Bis(2-Methoxyethoxy)Benzoic Acid
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE
CAS 179688-29-0
EINECS 605-867-4
InChI InChI=1/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
InChIKey PMQWTUWLIGJTQD-UHFFFAOYSA-N

6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one - Physico-chemical Properties

Molecular FormulaC14H18N2O5
Molar Mass294.3
Density1.26±0.1 g/cm3(Predicted)
Melting Point185-189°C
Boling Point467.8±55.0 °C(Predicted)
Flash Point236.7°C
Solubility DMSO: ≥10mg/mL
Vapor Presure6.3E-09mmHg at 25°C
AppearanceWhite crystal
Coloroff-white to light tan
pKa1.35±0.20(Predicted)
Storage ConditionInert atmosphere,Room Temperature
Refractive Index1.552
MDLMFCD02678087

6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one - Risk and Safety

WGK Germany3

6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one - Introduction

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.
Last Update：2022-10-16 17:14:31

6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one - Reference Information

Introduction 6, 7-dimethoxyquinazolin-4-one is an intermediate for the synthesis of erlotinib. Erlotinib, chemical name N-(3-acetylenephenyl)-6, 7-bis (2-methoxyethoxy)-4-quinolinamide, is a small molecule compound that can inhibit human epidermal growth factor receptor (EGFR) Signaling pathway, erlotinib inhibits tumor growth by inhibiting the activity of tyrosine kinase.
Last Update：2024-04-09 20:44:15
6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one
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View History
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