6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one
CAS: 179688-29-0
Molecular Formula: C14H18N2O5
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one - Names and Identifiers
| Name | 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one |
| Synonyms | ERLOTINIBINT-F Erlotinib iMpurity E Erlotinib'S Intermediate Erlotinib LactaM IMpurity 6,7-bis-Methoxyethoxy-quinazolin-4-one 6,7-Bis(2-Methoxyethoxy)Quinazolin-4(1H)-One 6,7-Bis(2-Methoxyethoxy)-3H-quinazolin-4-one 6,7-bis(2-methoxyethoxy)-1H-quinazolin-4-one 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE 6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one 6,7-Bis-(2-Methoxyethoxy)Quinazolin-4(3H)-One 6,7-Bis-(2-Methoxyethoxy)-4(3H)-Quinazolinone 6,7-Bis-(2-Methoxyethoxy)-Quinazolin-4(3H)-One 6,7-Bis(2-Methoxyethoxy)-3,4-Dihydroquinazolin-4-One Methyl Ester, 2-Amino-4,5-Bis(2-Methoxyethoxy)Benzoic Acid 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(1H)-ONE |
| CAS | 179688-29-0 |
| EINECS | 605-867-4 |
| InChI | InChI=1/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17) |
| InChIKey | PMQWTUWLIGJTQD-UHFFFAOYSA-N |
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one - Physico-chemical Properties
| Molecular Formula | C14H18N2O5 |
| Molar Mass | 294.3 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | 185-189°C |
| Boling Point | 467.8±55.0 °C(Predicted) |
| Flash Point | 236.7°C |
| Solubility | DMSO: ≥10mg/mL |
| Vapor Presure | 6.3E-09mmHg at 25°C |
| Appearance | White crystal |
| Color | off-white to light tan |
| pKa | 1.35±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.552 |
| MDL | MFCD02678087 |
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one - Risk and Safety
| WGK Germany | 3 |
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one - Introduction
CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.
Last Update：2022-10-16 17:14:31
6,7-Bis(2-methoxyethoxy)quinazolin-4-(3H)-one - Reference Information
| Introduction | 6, 7-dimethoxyquinazolin-4-one is an intermediate for the synthesis of erlotinib. Erlotinib, chemical name N-(3-acetylenephenyl)-6, 7-bis (2-methoxyethoxy)-4-quinolinamide, is a small molecule compound that can inhibit human epidermal growth factor receptor (EGFR) Signaling pathway, erlotinib inhibits tumor growth by inhibiting the activity of tyrosine kinase. |
Last Update：2024-04-09 20:44:15
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