6-(Methylsulfanyl)-1H-purin-2-amine
2-Amino-6-methylmercaptopurine
CAS: 1198-47-6
Molecular Formula: C6H7N5S
6-(Methylsulfanyl)-1H-purin-2-amine - Names and Identifiers
| Name | 2-Amino-6-methylmercaptopurine |
| Synonyms | 6-Methylthioguanine TIMTEC-BB SBB000228 2-Amino-6-methylthiopurine 2-AMINO-6-METHYLMERCAPTOPURINE 2-Amino-6-methylmercaptopurine 1H-Purin-2-amine, 6-(methylthio)- 6-(Methylsulfanyl)-1H-purin-2-amine 6-(METHYLSULFANYL)-7H-PURIN-2-YLAMINE |
| CAS | 1198-47-6 |
| EINECS | 214-833-4 |
| InChI | InChI=1/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2-3H,1H3,(H2,7,8,9,10) |
6-(Methylsulfanyl)-1H-purin-2-amine - Physico-chemical Properties
| Molecular Formula | C6H7N5S |
| Molar Mass | 181.22 |
| Density | 1.403 (estimate) |
| Melting Point | 235.5°C |
| Boling Point | 344.1°C at 760 mmHg |
| Flash Point | 161.9°C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Vapor Presure | 6.74E-05mmHg at 25°C |
| Appearance | solid |
| Color | White to Off-White |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.4606 (estimate) |
6-(Methylsulfanyl)-1H-purin-2-amine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S39 - Wear eye / face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29335995 |
6-(Methylsulfanyl)-1H-purin-2-amine - Nature
Open Data Verified Data
- This product is yellow crystalline powder; Odorless, slightly sweet taste. Slightly soluble in water and ethanol, practically insoluble in ether. Water of crystallization was lost at 140 °c. Soluble in alkaline aqueous solution, but very unstable, slow hydrolysis, light notes into black in the air. Soluble in boiling water. The melting point was 313-314 °c.
- This product is a purine antimetabolite, into the body into 6-mercaptopurine nucleotides, prevent inosinic acid into adenosine, xanthine nucleotides, inhibit the biosynthesis of Col. 6 A Mercaptopurine is hypoxanthine analogs, can competitively inhibit hypoxanthine into inosinic acid, prevent guanine into guanosine, so the inhibition of RNA and DNA synthesis, killing the proliferation of cells in each phase.
- oral absorption, 50% ~ 80% in the liver by xanthine oxidase oxidation to 6 a thiol uric acid. Its metabolites and part of the prototype are excreted by the urine. Long use has a certain accumulation, cancer cells are easy to produce drug resistance, but this drug-resistant cancer cells have increased sensitivity to methotrexate side sensitive phenomenon.
Last Update：2024-01-02 23:10:35
6-(Methylsulfanyl)-1H-purin-2-amine - Preparation Method
Open Data Verified Data
multi-step synthesis using cyanoacetate as raw material.
Last Update：2022-01-01 11:12:30
6-(Methylsulfanyl)-1H-purin-2-amine - Use
Open Data Verified Data
- Anti-tumor drug. Treatment of acute and chronic leukemia, choriocarcinoma and malignant mole, immune suppression.
- formulation specifications (tablets) (1) 25mg;(2) 50mg;(3) lOOmg.
- usage and dosage of oral, 1. 5~3mg per kilogram of body weight per day, divided into 2~3 times.
Last Update：2022-01-01 11:12:30
6-(Methylsulfanyl)-1H-purin-2-amine - Safety
Open Data Verified Data
- gastrointestinal reaction was Nausea, Vomit, decreased appetite, sometimes Diarrhea, stomatitis and oral ulcer. Bone marrow suppression is more obvious, white blood cells, platelet reduction, and even reduce the whole blood. Hemogram should be strictly checked during medication. A small number of patients can appear liver function damage and yellow
- ↑, which could be recovered after drug withdrawal. Liver function tests should be performed during administration. Liver and kidney dysfunction should be reduced with caution. When combined with allopurinol, allopurinol should be reduced to 25% ~ 50% of the original dose,
- under shading, sealed and preserved.
Last Update：2022-01-01 11:12:30
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CAS: 1198-47-6
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CAS: 1198-47-6
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