6-Methyl-3-aminopyridine
6-Methylpyridin-3-ylamine
CAS: 3430-14-6;80287-53-2
Molecular Formula: C6H8N2
6-Methyl-3-aminopyridine - Names and Identifiers
6-Methyl-3-aminopyridine - Physico-chemical Properties
| Molecular Formula | C6H8N2 |
| Molar Mass | 108.14 |
| Density | 1.068±0.06 g/cm3(Predicted) |
| Melting Point | 95-99°C |
| Boling Point | 238.4±20.0 °C(Predicted) |
| Flash Point | 121.09°C |
| Vapor Presure | 0.042mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | Off-white to orange to brown |
| pKa | 6.89±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.574 |
| MDL | MFCD00833389 |
6-Methyl-3-aminopyridine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R24/25 - |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S27 - Take off immediately all contaminated clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN2811 |
| WGK Germany | 3 |
| HS Code | 29333999 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
6-Methyl-3-aminopyridine - Reference Information
| LogP | 0.704 |
| introduction | pyridine compounds are one of the most widely developed and applied varieties of heterocyclic compounds at present. 5-amino -2-methylpyridine is an important fine chemical raw material, its derivatives mainly include alkyl pyridine, halogenated pyridine, aminopyridine, bromopyridine, methylpyridine, iodopyridine, chloropyridine, nitropyridine, hydroxypyridine, benzyl pyridine, ethyl pyridine, cyanopyridine, fluoropyridine, dihydropyridine, etc., of which pesticides account for about 50% of the total consumption of 5-amino-2-methylpyridine series products, feed additives are about 30%, and medicine and other fields account for 20%. |
| application | 5-amino -2-methylpyridine is an important pharmaceutical and chemical intermediate, and is an important raw material for organic synthesis industry, pharmaceutical industry, rubber industry and agricultural chemical products industry. It is widely used in the synthesis and development of medicines, pesticides, and veterinary drugs, and has high application value and market value. |
| preparation | (1) dissolve 1.54g(0.01mol) of 5-(2-methylfuran) ethyl formate in 15ml of dimethylformamide, add 0.80g(0.015mol) of ammonium chloride and 0.45g(0.01mol) of formamide, pass ammonia gas, reflux reaction for 24 hours, add dilute hydrochloric acid to adjust pH to 2, and extract ethyl acetate to retain water phase, adding sodium hydroxide solution to the aqueous phase to adjust the pH to neutral, ether extraction to retain the organic phase, concentration and drying to obtain 5-amino -3-hydroxy -2-methylpyridine 0.89g, the yield is 71.8%;(2) Add 0.89g(0.0072mol) of 5-amino -3-hydroxy -2-methylpyridine, 1.92g(0.014mol) of phosphorus trichloride and 0.73g(0.01mol) of dimethylformamide into 12ml of dichloroethane, refluxing for 6h, adding the concentrated mixture into ice water, adding a decolorant, adjusting the pH of the filtered solution to neutral, ethyl acetate extraction to retain organic phase, concentration and drying, 0.96g of 5-amino -3-chloro -2-methylpyridine was obtained with an yield of 93.9%;(3) Mix 0.96g(0.0067mol) of 2-amino -3-chloro -4-methylpyridine and 1.83g(0.015mol) of benzoic acid, add copper powder, react at 150 ℃ for 1h, add the reaction liquid to water, add decolorant, adjust the pH of the filtered solution to 9, filter, dry the filter cake to obtain 0.65g of yellow solid 5-amino -2-methylpyridine crude product with an yield of 89.3%. Dissolve 0.65g of crude 5-amino -2-methylpyridine in dilute hydrochloric acid solution until the crude product is completely dissolved to obtain a salt solution, add ethyl acetate to the salt solution to extract the water-retaining phase, slowly add sodium bicarbonate solution to the water phase, until the pH is 9, the solid is completely precipitated, filtered, distilled water washes the filter cake, and vacuum dries to obtain 0.53g of light yellow solid 5-amino -2-methylpyridine with a yield of 81.5%, 99.2% purity. |
Last Update：2024-04-09 21:11:58
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