6-n-Propyl-2-thiouracil
4-Hydroxy-2-mercapto-6-propylpyrimidine
CAS: 51-52-5
Molecular Formula: C7H10N2OS
6-n-Propyl-2-thiouracil - Names and Identifiers
6-n-Propyl-2-thiouracil - Physico-chemical Properties
| Molecular Formula | C7H10N2OS |
| Molar Mass | 170.23 |
| Density | 1.252g/cm3 |
| Melting Point | 218-221℃ |
| Boling Point | 355.2°Cat760mmHg |
| Water Solubility | 1.1 g/L |
| Solubility | Very slightly soluble in water, ether, slightly soluble in ethanol, soluble in alkaline hydroxide solution. |
| Appearance | White crystalline powder |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.609 |
| MDL | MFCD00006041 |
| Physical and Chemical Properties | This product is white crystalline or crystalline powder, odorless, bitter, slightly soluble in ethanol, very slightly soluble in water, dissolve in sodium hydroxide test solution or ammonia test solution. This product is non-toxic, non-anesthetic, not flammable and explosive. |
| Use | Antithyroid drugs used to combat hyperthyroidism, toxic goiter, or in preparation for thyroid surgery |
6-n-Propyl-2-thiouracil - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
6-n-Propyl-2-thiouracil - Upstream Downstream Industry
| Raw Materials | Methyl 3-oxohexanoate Ethyl butyrylacetate |
6-n-Propyl-2-thiouracil - Reference
| Reference Show more | 1. Wu Guotai, Liu Wuzhou, du Lidong, et al. Effect of Angelica volatile oil on reducing blood lipid and protecting vascular endothelium in hyperlipemia model rats [J]. Chinese Journal of arteriosclerosis, 2016, 24(010):989-993. 2. Tomangui Aji, Melena ay Isaac, Zhou Wenting, et al. Effects of total flavonoids of sinonovacula constricta on blood lipid and antioxidant capacity in hyperlipidemia rats [J]. Pharmacology and Clinic of Traditional Chinese Medicine, 2013, 29 (5):64-67. 3. Wei Jie, Li Yanjiao, Chen Xiaojun, etc. Protective effect of total flavonoids of Huangqi on aortic injury in type 2 diabetic rats with atherosclerosis [J]. Chinese traditional medicines, 2018, 040(007):1458-1463. 4. Wei Jie, Li Yanjiao, Chen Xiaojun, etc. Effect of total flavonoids of Huangqi on insulin resistance in rats with type 2 diabetes mellitus and atherosclerosis [J]. Chinese patent medicine, 2018, v.40(09):165-168. 5. Wu Guotai, Liu Wuzhou, niutaihui, et al. Protective effect of Angelica volatile oil on atherosclerosis in hyperlipidemic mice [J]. Chinese herbal medicines, 2016, 39(9):2102-2102. 6. Chen Li, Liao Liangying, Dai Fei, Wang Yu, Zhang Yang, Chen Minmin, Huang Jieya, Ye Yongxin, Zhou Zhongzhi. Mechanism of Jiedu Shengji ointment on skin micro-ecological balance of diabetic ulcer [J]. Jilin Journal of Traditional Chinese Medicine, 2021,41(02):225-229. 7. Chen Li, Wang xiaofrost, Zhou Zhongzhi, Zhao Siru, Hu Jinting, Tan Yan, Gao Lantian, Wang Tingting. Effect of Xian-root-ru-pu formula on wound healing and mitochondria of skin ulcer in diabetic rats [J]. Tianjin Journal of Traditional Chinese Medicine, 2021,38(01):93-97. 8. Umar, Anwar, et al. "Effects of Cydonia oblonga Miller leaf and fruit flavonoids on blood lipids and anti-oxydant potential in hyperlipidemia rats." Journal of ethnopharmacology 169 (2015): 239-243.https://doi.org/10.1016/j.jep.2015.04.038 9. Han, Shu, et al. "Anemarrhenae Rhizoma: Material Basis and Mechanism of Its Renal-Yin-Deficiency Syndrome Treating Effect and Its Effect Enhancement after Salt Stir-frying ." (2020). 10. [IF=4.36] Anwar Umar et al."Effects of Cydonia oblonga Miller leaf and fruit flavonoids on blood lipids and anti-oxydant potential in hyperlipidemia rats."J Ethnopharmacol. 2015 Jul;169:239 |
6-n-Propyl-2-thiouracil - Standard
Authoritative Data Verified Data
This product is 6-propyl-2-thio-2, 3-dihydro-4 (1H) pyrimidinone. The content of C7H10N2OS shall not be less than 98.0% calculated as dried product.
Last Update：2024-01-02 23:10:35
6-n-Propyl-2-thiouracil - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is slightly soluble in ethanol and slightly soluble in water; It is dissolved in sodium hydroxide test solution or ammonia test solution.
melting point
The melting point of this product (General 0612) is 218~221°C.
Last Update：2022-01-01 11:35:14
6-n-Propyl-2-thiouracil - Differential diagnosis
Authoritative Data Verified Data
- take the saturated aqueous solution of this product, heat to boiling, and add equal amount of new mixed solution containing 0.4% sodium nitrosoferricyanide, 0.4% hydroxylamine hydrochloride and 0.8% sodium carbonate, which shows green and blue color.
- take about 25mg of this product, drop the bromine test solution to completely dissolve, heat, fade, let cool, drop the barium hydroxide test solution, and generate white precipitate.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 70).
- an appropriate amount of this product and the reference product of propylthiouracil were respectively dissolved by adding an appropriate amount of methanol, and then diluted with water to prepare a solution containing about 25ug per 1 ml as a test solution and a reference solution. According to the chromatographic conditions under the relevant substances, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution in the recorded chromatogram.
Last Update：2022-01-01 11:35:14
6-n-Propyl-2-thiouracil - Exam
Authoritative Data Verified Data
thiourea
take about 50mg of this product, put it in a 100ml measuring flask, add appropriate amount of mobile phase to dissolve and dilute to the scale, shake well, take 10ml accurately, put it in a 50ml measuring flask, dilute with mobile phase to the scale, shake, as a test solution; Another precision weigh the appropriate amount of thiourea reference, add the appropriate amount of mobile phase to dissolve and quantitatively dilute to make about 0 per 1 ml. lug solution, as a control solution. According to the high performance liquid chromatography (General 0512) test, with eighteen alkyl silane bonded silica gel as filler, water-acetonitrile (60:40) as mobile phase, the flow rate was 0.5 per minute, the detection wavelength was 238nm. The resolution of the thiourea peak from the adjacent peak shall meet the requirements. 20 u1 of the test solution and the reference solution were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there is a thiourea peak in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, and the peak area shall not exceed 0.1%.
Related substances
take about 50mg of this product, put it in a 100ml measuring flask, add 5ml of methanol, shake for 10 minutes, add 50ml of water, shake for 20 minutes, dilute to the scale with water, shake, filter, take 10ml of the continued filtrate, put it in a 50ml measuring flask, dilute it to the scale with water, shake it well, and use it as a test solution. Take 1ml of the precise measurement, put it in a 100ml measuring flask, and dilute it to the scale with water, as a control solution. According to the high performance liquid chromatography (General 0512) test, using eighteen alkyl silane bonded silica gel as filler, 0.02mol/L phosphate buffer (take potassium dihydrogen phosphate 3.40g, add water to dissolve, with phosphoric acid or 0. The pH value of 1 mol/L sodium hydroxide solution was adjusted to 4.6, and the mixture was diluted to 1000ml with water to obtain acetonitrile (70:30) as mobile phase, and the detection wavelength was 273nm. The number of theoretical plates shall not be less than 2000 calculated by propylthiouracil peak, and the separation degree between the main peak and the adjacent impurity peak shall meet the requirements. 20ul of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:35:15
6-n-Propyl-2-thiouracil - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add water 30ml, with a burette plus sodium hydroxide titration solution (0.1 mol/L )30ml boiled and shake dissolved, plus 0.1 mol/L silver nitrate solution 50ml, continue to heat and keep it slightly boiling for about 7 minutes, cool, according to the potential titration method (General 0701), continue to use sodium hydroxide titration solution (0.lmol/L) titration. Each l of sodium hydroxide titration solution (0.1 mol/ L) corresponds to 8.512mg of C7H10N2OS.
Last Update：2022-01-01 11:35:16
6-n-Propyl-2-thiouracil - Category
Authoritative Data Verified Data
antithyroid drugs.
Last Update：2022-01-01 11:35:16
6-n-Propyl-2-thiouracil - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:35:16
6-n-Propyl-2-thiouracil - Propylthiouracil Tablets
Authoritative Data Verified Data
This product contains propylthiouracil (C7H10N2OS) should be labeled the amount of 93.0% to 107.0%.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.2g of propylthiouracil), add 10ml of ethanol, heat and reflux for 20 minutes, take advantage of heat filtration, and evaporate the filtrate on a water bath, the residue showed the same reaction according to the tests of identification (1) and (2) under propylthiouracil.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of fine powder of this product (about 0.1g of propylthiouracil), add 20ml of ethanol, shake, filter, evaporate the filtrate to dryness, dry the residue under reduced pressure, and determine according to law. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 70).
examination
- relevant substances: take an appropriate amount of fine powder of this product (about 50mg of propylthiouracil), put it in a 100ml measuring flask, add 5ml of methanol, shake it for 10 minutes, add 50ml of water, and shake it for 20 minutes to dissolve propylthiouracil, dilute to the scale with water, shake, filter, take the filtrate 10ml accurately, put it in 50ml measuring flask, dilute to the scale with water, shake, as a test solution; take 1 ml of precision, 100ml flask, diluted with water to scale, shake, as a control solution. According to the chromatographic conditions under the content determination item, 20 U1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, take 10ml of the solution, filter, take the appropriate amount of the filtrate, dilute with water to make a solution containing propylthiouracil in about 1 ml, according to ultraviolet-visible spectrophotometry (General 0401 ), measure absorbance at the wavelength of 274nm; Accurately weigh about 25mg of propylthiouracil control, put it in a 100ml measuring flask, add 20ml of ethanol, dissolve by ultrasound, cool, dilute to the scale with water, shake, precision take appropriate amount, quantitative dilution with water to make a solution containing about 5ug per lml, the same method to determine, calculate the dissolution of each tablet. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as a filler; 0.02mol/L phosphate buffer (Take 3.40g of potassium dihydrogen phosphate, add of water to dissolve, with phosphoric acid or 0. The pH value of 1 mol/L sodium hydroxide solution was adjusted to 4.6 and diluted to ML with water to obtain acetonitrile (70:30) as mobile phase; The detection wavelength was 273mn. The number of theoretical plates shall not be less than 2000 based on the calculation of propylthiouracil peak, and the separation degree between propylthiouracil peak and adjacent impurity peaks shall meet the requirements.
- determination of 20 tablets of this product, precision weighing, fine, precision weighing an appropriate amount (about 50mg equivalent to propylthiouracil), 100ml flask, add methanol 5ml, shake for 10 minutes, add 50ml of water, shake for 20 minutes to dissolve propylthiouracil, dilute to scale with water, shake well, filter; Take 10ml of continued filtrate in a 100ml flask, dilute to scale with water, shake well, as a test solution, accurately measure 20u1 and inject human liquid chromatograph, record the chromatogram; Accurately weigh about 25mg of propylthiouracil, put it in a 50ml measuring flask, and add 2.5 of methanol, shake for 10 minutes, add 25ml of water, shake for 20 minutes, dilute to scale with water, shake well, take 10ml of filtrate precisely, put it in a 100ml measuring flask, dilute to scale with water, shake well, same method determination. According to the external standard method to calculate the peak area, that is.
category
Same as propylthiouracil.
specification
(l)50mg (2)100mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:35:17
6-n-Propyl-2-thiouracil - Propylthiouracil enteric-coated tablets
Authoritative Data Verified Data
This product contains propylthiouracil (07H10N2OS) should be labeled the amount of 93.0% to 107.0%.
trait
This product is an enteric-coated tablet, White after removing the coating.
identification
- take an appropriate amount of fine powder of this product (about 0.2g of propylthiouracil), add 10ml of ethanol, heat and reflux for 20 minutes, warm and filter, and evaporate the filtrate on a water bath, the residue showed the same reaction according to the tests of identification (1) and (2) under propylthiouracil.
- the sample solution under the content measurement item was taken and measured by ultraviolet-visible spectrophotometry (General rule 0401), and there was a maximum absorption at a wavelength of 274nm.
examination
- Related substances take an appropriate amount of fine powder of this product (about 50mg equivalent to propylthiouracil), put it in a 100ml measuring flask, add 5ml of methanol, shake it for 10 minutes, add 50ml of water, and shake it for 20 minutes, dissolve propylthiouracil, dilute to the scale with water, shake well, filter, take a precise amount of filtrate 10ml, put it in a 50ml measuring flask, dilute to the scale with water, shake well, as a test solution; take 1 ml of precision, 100ml flask, diluted with water to scale, shake, as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 3 times of the retention time of the main component peak, if there are impurity bees in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
- out of the taking this product, according to the dissolution and release determination method (General rule 0931 first method 2) determination, with 0.100 ml of 1 mol/L hydrochloric acid solution is the dissolution medium, and the rotation speed is revolutions per minute. After 2 hours, the rotating basket is immediately lifted out of the liquid surface, and each piece is not allowed to crack or disintegrate, and take the appropriate amount of solution, filtration, take the continued filtrate as the test solution; Take the appropriate amount of propylthiouracil control, precision weighing, with 0.1 mol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing about 5.5ug per 1 ml as a control solution. The absorbance of each of the above two Solutions was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (general), and the amount of acid dissolved in each tablet was calculated. The amount of acid dissolved shall not be more than 10% of the labeled amount and shall be in accordance with the provisions. The rotating basket was then immersed in human phosphate buffer (0.1 mol/L hydrochloric acid solution and 0.2mol/L sodium phosphate solution, mix evenly according to 3:1, adjust the pH value to 6.8 with 2mol/L hydrochloric acid solution or 2mol/L sodium hydroxide solution if necessary) continue to operate in accordance with the law in 900ml of solvent. After 45 minutes, take 10ml of the solution, filter it, take 5ml of the filtrate with precision, put it in a 50ml measuring flask, and dilute it to the scale with the above phosphate buffer solution, shake, as a test solution; Another appropriate amount of propylthiouracil control, precision weighing, dissolving and quantitatively diluting with the above phosphate buffer to prepare a solution containing about 5.5ug per 1 ml, as a reference solution. The absorbance of each of the above two Solutions was measured at a wavelength of 274mn by ultraviolet-visible spectrophotometry (General 0401), and the amount of elution in the buffer solution of each tablet was calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as a filler, 0.02mol/L phosphate buffer (Take 3.40g of potassium dihydrogen phosphate, add water to dissolve, with phosphoric acid or 0. The pH value of 1 mol/L sodium hydroxide solution was adjusted to 4.6, and the mixture was diluted to 1000ml with water to obtain acetonitrile (70:30) as mobile phase, and the detection wavelength was 273mn. The number of theoretical plates shall not be less than 2000 based on the calculation of propylthiouracil peak, and the separation degree between propylthiouracil peak and adjacent impurity peaks shall meet the requirements.
- determination of 20 tablets of this product, precision weighing, fine, precision weighing an appropriate amount (about 50mg equivalent to propylthiouracil), 100ml flask, add methanol 5ml, shake for 10 minutes, add 50ml of water, shake for 20 minutes, dissolve propylthiouracil, dilute to scale with water, shake, filter, take 10ml of continued filtrate in a 100ml measuring flask, dilute to scale with water, shake well, as a test solution, accurately measure 20u1 and inject human liquid chromatograph, record the chromatogram; Accurately weigh about 25mg of propylthiouracil, put it in a 50ml measuring flask, and add 2.5 of methanol, shake for 10 minutes, add water 25ml, shake for 20 minutes, dilute to scale with water, shake well, take 10ml with precision, put in 100ml measuring flask, dilute to scale with water, shake well, and measure with the same method. According to the external standard method to calculate the peak area, that is.
category
Same as propylthiouracil.
specification
50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:35:18
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Raw Materials for 6-n-Propyl-2-thiouracil