Molecular Formula | C12H10F3N3O4 |
Molar Mass | 317.22 |
Density | 1.463±0.06 g/cm3(Predicted) |
Melting Point | 1490C |
Appearance | morphological solid |
pKa | 7.59±0.70(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Physical and Chemical Properties | Chemical properties crystallize from ethanol, melting point 149 ℃. Acute toxic LD50 male mice, male rats (mg/kg):215,195 oral; 180,135 intraperitoneal injection. |
Use | Use non-steroidal anti-androgen, but no effect on other steroid receptors. For metastatic prostate cancer. |
Hazard Symbols | T - Toxic |
Risk Codes | R60 - May impair fertility R25 - Toxic if swallowed |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | NI9453300 |
HS Code | 2933210000 |
Raw Materials | Isopropylamine Phenyl isocyanate Dimethyl sulfoxide COPPER(II) OXIDE Diphenyl ether 5,5-Diphenylhydantoin |
Solubility | Very slightly soluble in water, freely soluble in acetone, soluble in anhydrous ethanol. |
biological activity
Nilutamide (RU23908) is a non-steroidal anti-androgen drug with affinity for androgen receptors. For the treatment of prostate cancer.
Target
Target Value
Androgen Receptor
Production method
49.6g 3-trifluoromethyl-4-nitrophenyl isocyanate reacts with 18g α-cyano isopropylamine to obtain 27g compound (Ⅰ). Then acidic hydrolysis to obtain Nilutamide.