662163-81-7

Name	N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
Synonyms	CS-2426 ImportazoL Importazole N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine 4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)-
CAS	662163-81-7

Molecular Formula	C20H22N4
Molar Mass	318.42
Density	1?+-.0.06 g/cm3(Predicted)
Boling Point	516.8±42.0 °C(Predicted)
Solubility	DMSO: >5mg/mL
Appearance	powder
Color	white to beige
pKa	7.27±0.59(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
In vitro study	Importazole is a potent inhibitor of the Ran/importin-β interaction in vitro. Importazole specifically inhibited importin-β-mediated nuclear entry in Xenopus oocyte extracts and cultured cells, without disrupting transportin-mediated nuclear entry or CRM1-mediated nuclear exit. The addition of importazole during cell mitosis inhibits/disrupts the release of the importin-β cargo FRET probe, resulting in defects in spindle assembly. Importazole can inhibit cell proliferation and induce apoptosis of multiple myeloma cells by inhibiting NF-κB signaling pathway in vitro.

WGK Germany

Last Update：2024-01-02 23:10:35

, it can specifically inhibit the nuclear entry reaction mediated by importin-β. Import induces apoptosis and inhibits tumor growth.

biological activity
Target	Value

Last Update：2024-04-10 22:29:15

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662163-81-7

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