ImportazoL
N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
CAS: 662163-81-7
Molecular Formula: C20H22N4
ImportazoL - Names and Identifiers
ImportazoL - Physico-chemical Properties
| Molecular Formula | C20H22N4 |
| Molar Mass | 318.42 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Boling Point | 516.8±42.0 °C(Predicted) |
| Solubility | DMSO: >5mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 7.27±0.59(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | Importazole is a potent inhibitor of the Ran/importin-β interaction in vitro. Importazole specifically inhibited importin-β-mediated nuclear entry in Xenopus oocyte extracts and cultured cells, without disrupting transportin-mediated nuclear entry or CRM1-mediated nuclear exit. The addition of importazole during cell mitosis inhibits/disrupts the release of the importin-β cargo FRET probe, resulting in defects in spindle assembly. Importazole can inhibit cell proliferation and induce apoptosis of multiple myeloma cells by inhibiting NF-κB signaling pathway in vitro. |
ImportazoL - Risk and Safety
| WGK Germany | 3 |
ImportazoL - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.141 ml | 15.703 ml | 31.406 ml |
| 5 mM | 0.628 ml | 3.141 ml | 6.281 ml |
| 10 mM | 0.314 ml | 1.57 ml | 3.141 ml |
| 5 mM | 0.063 ml | 0.314 ml | 0.628 ml |
Last Update：2024-01-02 23:10:35
ImportazoL - Reference Information
| biological activity | , it can specifically inhibit the nuclear entry reaction mediated by importin-β. Import induces apoptosis and inhibits tumor growth.|
| Target | Value |
Last Update：2024-04-10 22:29:15
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Tel: 18301782025
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Spot supply
Product Name: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine Visit Supplier Webpage Request for quotationCAS: 662163-81-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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