66742-57-2
4-(3-fluorobenzyloxy)benzaldehyde
CAS: 66742-57-2
Molecular Formula: C14H11FO2
66742-57-2 - Names and Identifiers
66742-57-2 - Physico-chemical Properties
| Molecular Formula | C14H11FO2 |
| Molar Mass | 230.23 |
| Density | 1.211±0.06 g/cm3(Predicted) |
| Melting Point | 46.0 to 50.0 °C |
| Boling Point | 265°C/3mmHg(lit.) |
| Flash Point | 167.6°C |
| Vapor Presure | 1.83E-05mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.59 |
| Physical and Chemical Properties | 4-(3-fluorobenzyloxy) benzaldehyde is white to off-white solid at room temperature and pressure. It is a benzaldehyde derivative. It is easy to be oxidized by air for a long time at room temperature to generate the corresponding benzoic acid Compound, so it is generally required to be stored at low temperature (2 to 8 degrees). |
| Use | This product is for scientific research only and shall not be used for other purposes. |
66742-57-2 - Risk and Safety
| Hazard Class | IRRITANT |
66742-57-2 - Reference Information
| Chemical properties | 4-(3-fluorobenzyloxy) benzaldehyde is a white to off-white solid at normal temperature and pressure, which is a benzaldehyde derivative and is easily oxidized by air at room temperature for a long time to generate corresponding benzoic acid compounds, therefore, it is generally required to be stored at low temperature (2 to 8 degrees). |
| Use | 4-(3-fluorobenzyloxy) benzaldehyde can be used as an intermediate in organic synthesis for laboratory research and development and drug molecule synthesis. In organic synthesis, the aldehyde group in the structure can be converted into carboxyl group by oxidation or into hydroxyl group by reduction reaction; in addition, the aldehyde group can also be used to obtain the corresponding olefin derivative by wittig reaction. |
| synthetic method | with stirring, potassium carbonate (5.27G, 38.19 mmol, 1.10 equiv.) and potassium iodide (0.58g, 3.47 mmol, 0.10 eq) was added slowly to 4-hydroxybenzaldehyde (36.46 mmol, 1.05 eq) and 3-fluorobenzyl chloride (5.00g, 34.72 mmol, 1.00 equiv) in ethanol (30ml) suspension, the reaction mixture was refluxed at 85 degrees for 12-18 hours, the solvent was then removed under vacuum. Water (30 mL) was added and the mixture was stirred for 3 H. The crude product was filtered and dissolved in dichloromethane (20 mL) followed by water (10 mL). The mixture was washed and the resulting organic phase was dried over anhydrous sodium sulfate, the organic phase was evaporated under vacuum and the residue was purified by Silica Gel chromatography with (petroleum ether: ethyl acetate = 5:1(v/v)) elution to obtain 4-(3-fluorobenzyloxy) benzaldehyde. Figure 4-(3-fluorobenzyloxy) benzaldehyde synthesis |
Last Update：2024-04-09 20:52:54
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