7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one - Names and Identifiers
7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one - Physico-chemical Properties
Molecular Formula | C10H6F3NO
|
Molar Mass | 213.16 |
Density | 1.3581 (estimate) |
Melting Point | 266-269°C(lit.) |
Boling Point | 311.9±37.0 °C(Predicted) |
Appearance | Powder |
Color | Light grayish to beige |
pKa | 3.79±0.40(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.629 |
7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
|
WGK Germany | 3 |
HS Code | 29334990 |
Hazard Class | IRRITANT |
7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one - Introduction
7-(Trifluoromethyl)-4-quinolinol, also known as 7-(Trifluoromethyl)-4-quinolinol, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 7-(Trifluoromethyl)-4-quinolinol is a white to light yellow crystalline or powdery solid.
-Solubility: It has good solubility in common organic solvents.
Use:
-Chemical reagent: 7-(Trifluoromethyl)-4-quinolinol can be used as a reagent in organic synthesis reactions, such as selective dehydration, oxidation and reduction of aldehyde groups.
-Drug research: It is widely used as an intermediate and reagent for drug synthesis in drug research.
Method:
7-(Trifluoromethyl)-4-quinolinol can be prepared by the following steps:
-The first step: 4-chloroquinoline reacts with trifluoromethyl alcohol to produce 4-chloro-7-trifluoromethylquinoline.
-The Second step: 4-chloro-7-trifluoromethylquinoline is catalytically reduced with aluminum powder in water to obtain 7-(Trifluoromethyl)-4-quinolinol.
Safety Information:
- 7-(Trifluoromethyl)-4-quinolinol has low toxicity, but as an organic compound, it is still necessary to pay attention to safe operation.
-It may be irritating to the eyes and skin, and direct contact should be avoided when in contact.
-Follow Good Laboratory safety practices, such as wearing gloves, glasses and protective clothing.
Last Update:2024-04-09 19:05:49