7-CHLORO-4-QUINAZOLINOL
7-chloroquinazolin-4(1H)-one
CAS: 31374-18-2
Molecular Formula: C8H5ClN2O
7-CHLORO-4-QUINAZOLINOL - Names and Identifiers
| Name | 7-chloroquinazolin-4(1H)-one |
| Synonyms | AFA-IM C 7-CHLORO-4-QUINAZOLINOL 7-CHLOROQUINAZOLIN-4-OL 7-chloroquinazolin-4-ol 7-Chloroquinazolin-4-one 4-quinazolinol, 7-chloro- 7-Chloro-4(3H)-quinazolone 7-chloroquinazolin-4(1H)-one 7-CHLORO-4(1H)-QUINAZOLINONE 7-Chloroquinazolin-4(3H)-one 7-chloro-1H-quinazolin-4-one 7-CHLORO-4-HYDROXYQUINAZOLINE 4(3H)-Quinazolinone, 7-chloro- 7-Chloro-4-hydroxyquinazoline 7-CHLORO-3,4-DIHYDROQUINAZOLIN-4-ONE |
| CAS | 31374-18-2 |
| EINECS | 207-219-2 |
| InChI | InChI=1/C8H5ClN2O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,(H,10,11,12) |
7-CHLORO-4-QUINAZOLINOL - Physico-chemical Properties
| Molecular Formula | C8H5ClN2O |
| Molar Mass | 180.59 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Melting Point | 251-253 °C |
| Boling Point | 331.7±44.0 °C(Predicted) |
| Flash Point | 171.454°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 0.36±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.71 |
7-CHLORO-4-QUINAZOLINOL - Introduction
7-chloroquinazolin-4(1H)-one(7-chloroquinazolin-4(1H)-one) is an organic compound with the chemical formula C8H5ClN2O. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 7-chloroquinazolin-4(1H)-one is a white solid.
-Melting point: Its melting point range is usually between 150-153°C.
-Solubility: 7-chloroquinazolin-4(1H)-one has limited solubility in common organic solvents.
Use:
-Drug: 7-chloroquinazolin-4(1H)-one can be used as an intermediate for the synthesis of biologically active compounds, such as drugs or pesticides.
Method:
The preparation of 7-chloroquinazolin-4(1H)-one can usually be completed by the following steps:
1. Pyridine and acetone anhydride react to generate β-pyridyl pyruvate.
2. Under the catalysis of hydrogen chloride, β-pyridyl pyruvate and stannous bromide react to generate 7-bromo -4(3H)-quinazolinone.
3. Finally, 7-chloroquinazolin-4(1H)-one can be obtained by treating 7-bromo-4 (3H)-quinazolinone with copper chloride.
Safety Information:
- 7-chloroquinazolin-4(1H)-one is an organic compound with certain safety risks. During use, appropriate laboratory safety measures are required, including wearing protective gloves and eyes, and operating in well-ventilated conditions.
-It may cause irritation and harm to the skin, eyes and respiratory tract, so avoid contact with the skin and avoid inhaling its dust or gas.
-Be careful in handling and storage to avoid contact with substances such as oxidants and strong acids to prevent dangerous situations such as fire or explosion.
-Seek medical help immediately in case of any accident or discomfort.
Nature:
-Appearance: 7-chloroquinazolin-4(1H)-one is a white solid.
-Melting point: Its melting point range is usually between 150-153°C.
-Solubility: 7-chloroquinazolin-4(1H)-one has limited solubility in common organic solvents.
Use:
-Drug: 7-chloroquinazolin-4(1H)-one can be used as an intermediate for the synthesis of biologically active compounds, such as drugs or pesticides.
Method:
The preparation of 7-chloroquinazolin-4(1H)-one can usually be completed by the following steps:
1. Pyridine and acetone anhydride react to generate β-pyridyl pyruvate.
2. Under the catalysis of hydrogen chloride, β-pyridyl pyruvate and stannous bromide react to generate 7-bromo -4(3H)-quinazolinone.
3. Finally, 7-chloroquinazolin-4(1H)-one can be obtained by treating 7-bromo-4 (3H)-quinazolinone with copper chloride.
Safety Information:
- 7-chloroquinazolin-4(1H)-one is an organic compound with certain safety risks. During use, appropriate laboratory safety measures are required, including wearing protective gloves and eyes, and operating in well-ventilated conditions.
-It may cause irritation and harm to the skin, eyes and respiratory tract, so avoid contact with the skin and avoid inhaling its dust or gas.
-Be careful in handling and storage to avoid contact with substances such as oxidants and strong acids to prevent dangerous situations such as fire or explosion.
-Seek medical help immediately in case of any accident or discomfort.
Last Update：2024-04-09 21:00:56
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