7-CHLOROINDAZOLE
7-CHLORO-1H-INDAZOLE
CAS: 37435-12-4
Molecular Formula: C7H5ClN2
7-CHLOROINDAZOLE - Names and Identifiers
| Name | 7-CHLORO-1H-INDAZOLE |
| Synonyms | 7-CHLOROINDAZOLE 7-CHLORO-1H-INDAZOLE 1H-Indazole, 7-chloro- |
| CAS | 37435-12-4 |
7-CHLOROINDAZOLE - Physico-chemical Properties
| Molecular Formula | C7H5ClN2 |
| Molar Mass | 152.58 |
| Density | 1.425±0.06 g/cm3(Predicted) |
| Melting Point | 135-137 |
| Boling Point | 309.5±15.0 °C(Predicted) |
| pKa | 11.93±0.40(Predicted) |
| Storage Condition | 2-8°C |
7-CHLOROINDAZOLE - Risk and Safety
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN2811 |
| Hazard Class | IRRITANT |
7-CHLOROINDAZOLE - Reference Information
| introduction | 7-chloroindazole is a pharmaceutical intermediate, which can be obtained from 3-chloro-2-hydroxybenzaldehyde as raw material and linked to hydrazine hydrochloride. it is reported in the literature that it can be used to prepare SYK inhibitors. |
| Preparation | In a 250 mL flask, add hydrazine hydrochloride (excess) to a solution of 3-chloro-2-hydroxybenzaldehyde (36.7 mmol) in EtOH(30 mL). The solution was refluxed for 3 hours. The solvent is distilled under reduced pressure. The residue was purified by silica gel column chromatography (EtOAc∶PE = 10 ∶ 1) to give 7-chlorindazole. |
Last Update：2024-04-09 02:00:00
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View History
7-CHLOROINDAZOLE
2,5-二甲基环己酮 (异构体混合物)
1,3-金刚烷二羰酰氯
2-((((9H-芴-9-基)甲氧基)羰基)氨基)-3-苯丙酸
N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
3-(哌啶-4-基)-1氢-吲唑盐酸盐
2-溴乙基乙基醚(2-8°C)
2-甲苯磺酰氯
3-氨基-4-甲基-噻吩-2-羟基
2,5-二甲基环己酮 (异构体混合物)
1,3-金刚烷二羰酰氯
2-((((9H-芴-9-基)甲氧基)羰基)氨基)-3-苯丙酸
N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
3-(哌啶-4-基)-1氢-吲唑盐酸盐
2-溴乙基乙基醚(2-8°C)
2-甲苯磺酰氯
3-氨基-4-甲基-噻吩-2-羟基