87392-05-0
(R)-tetrahydrofuran-2-carboxylic acid
CAS: 87392-05-0
Molecular Formula: C5H8O3
87392-05-0 - Names and Identifiers
87392-05-0 - Physico-chemical Properties
| Molecular Formula | C5H8O3 |
| Molar Mass | 116.12 |
| Density | 1.209g/mLat 25°C(lit.) |
| Boling Point | 128-129°C13mm Hg(lit.) |
| Specific Rotation(α) | +19.6±0.2°(neat) (D/20℃) |
| Flash Point | >230°F |
| Vapor Presure | 0.0107mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| BRN | 4658739 |
| pKa | 3.60±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.46(lit.) |
87392-05-0 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| UN IDs | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| HS Code | 29321900 |
| Hazard Class | 8 |
| Packing Group | III |
87392-05-0 - Reference Information
| Overview | (R)-tetrahydrofuran carboxylic acid is an important pharmaceutical intermediate, the effectiveness of its stereoisomers has attracted attention. P.C.Belanger et al. (Can.J.Chem.61,1383(1983)) first reported an efficient resolution of this compound. However, in this method, Brucine dihydrate, which is extremely toxic and expensive, is used as a resolving agent. In addition, this method has the problems of low yield of the product and low recovery rate of the resolving agent. In order to solve these problems and adapt the resolution process to the needs of industrial production, researchers have done a lot of research from the separation agent, reaction solvent and so on. |
| Application | (R)-tetrahydrofuran carboxylic acid can be used in the preparation of azosin class treatment of hypertension drugs alfuzosin, terazosin, treatment of prostate cancer drugs, as well as the synthesis of cephalosporin antibiotic intermediates and chiral auxiliary (R)-acetyl tetrahydrofuran. At present, only furan formic acid is produced in China, and (R)-tetrahydrofuran formic acid is not produced yet. The price of R-tetrahydrofuran formic acid after resolution is as high as 1500 US dollars/B. At present, the domestic research on zosin products is active, and there are many manufacturers. There will be a great demand for (R)-tetrahydrofuran carboxylic acid. |
Last Update：2024-04-09 20:44:15
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