Name | A2ti-2 |
Synonyms | A2ti-2 Acetamide, 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- |
CAS | 482646-13-9 |
Molecular Formula | C18H18N4O2S |
Molar Mass | 354.43 |
Storage Condition | -20°C,干燥,密封 |
In vitro study | A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM. |
Biological activity | A2ti-2 is selective, low affinity annexin A2/S100A10 isotetramer (A2t) inhibitor, IC50 is 230 μM. A2ti-2 specifically disrupt the protein interaction between A2 and S100A10. A2ti-2 can prevent human papillomavirus type 16 (HPV16) infection. |
target | IC50: 230 μM (A2t) |
in vitro study | A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μ m. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μ m. |