ABT450
Paritaprevir
CAS: 1216941-48-8
Molecular Formula: C40H43N7O7S
ABT450 - Names and Identifiers
ABT450 - Physico-chemical Properties
| Molecular Formula | C40H43N7O7S |
| Molar Mass | 765.88 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 4.41±0.60(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In Vitro, Paritaprevir inhibits p-gp. Paritaprevir (ABT-450) is a potent inhibitor of HCV NS3/4A protease, and EC50 of stable HCV replicon containing NS3 protease genotypes 1a, 1b, 2a, 3a, 4a and 6a is 1, respectively, 0.21, 5.3, 19, 0.09 and 0.69 nM. The ABT-450 has a CC50 greater than 37 μm and an in vitro selectivity index greater than 37,000-fold. It is active against multiple HCV genotypes with an EC50 of 5.3 nM against JFH-1 subgene replicon cells of genotype 2a. |
| In vivo study | By the oral route, paritaprevir reaches a maximum blood concentration within 4-5 h, and the increase in the level of drug exposure exceeds the dose ratio. When administered with food, its oral bioavailability is about 50%. In Vivo, paritaprevir has a high plasma protein binding rate with an apparent volume of distribution of 16.7 L. It is mainly metabolized by CYP3A4 and CYP3A5. |
ABT450 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.306 ml | 6.528 ml | 13.057 ml |
| 5 mM | 0.261 ml | 1.306 ml | 2.611 ml |
| 10 mM | 0.131 ml | 0.653 ml | 1.306 ml |
| 5 mM | 0.026 ml | 0.131 ml | 0.261 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Paritaprevir Visit Supplier Webpage Request for quotationCAS: 1216941-48-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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