ACIDUM-NICOTINICUM

ACIDUM-NICOTINICUM - Names and Identifiers

Name	Nicotinic acid
Synonyms	VB3 Niacin NICOTINIC ACID Nicotinic acid 3-PICOLINIC ACID 3-Picolinic Acid 3-Carboxypyridine 3-CARBOXYPYRIDINE AKOS BBS-00003719 ACIDUM-NICOTINICUM 3-Carboxy Pyridine Acidum-Nicotinicum RARECHEM AL BO 0217 Beta-Picolinic Acid BETA-PICOLINIC ACID TIMTEC-BB SBB004279 pyridine-3-carboxylate TIMTEC-BB SBB004279123.11 pyridine-3-carboxylic acid Pyridine -3-Carloxylic acid
CAS	59-67-6
EINECS	200-441-0
InChI	InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChIKey	PVNIIMVLHYAWGP-UHFFFAOYSA-N

ACIDUM-NICOTINICUM - Physico-chemical Properties

Molecular Formula	C6H5NO2
Molar Mass	123.11
Density	1.473
Melting Point	236-239°C(lit.)
Boling Point	260C
Flash Point	193°C
Water Solubility	1-5 g/100 mL at 17 ºC
Solubility	18g/l
Vapor Presure	0.000836mmHg at 25°C
Appearance	Powder
Color	White to off-white
Merck	14,6525
BRN	109591
pKa	4.85(at 25℃)
PH	2.7 (18g/l, H2O, 20℃)
Storage Condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents. May be light sensitive.
Refractive Index	1.5423 (estimate)
Physical and Chemical Properties	White Crystal or crystalline powder, odorless or slightly odorous, with slightly sour taste
Use	Nicotinic acid is an important hydrogen-delivering body in the body tissue and anti-skin disease factor, maintain the skin and nerve health, promote the role of digestion. Dosage 30-80mg/kg. Nicotinic acid is an important hydrogen-delivering body in the body tissue and anti-skin disease factor, maintain the skin and nerve health, promote the role of digestion. China's provisions can be used to strengthen cereals and their products, the use of 40~50mg/kg; In fortified foods for infants and young children in the use of 30~40mg/kg; the amount used is 10-40mg/kg in the drink and milk drink. In addition, it can also be used as a feed additive and a color aid for meat products. This product is a vitamin drug, used for antibiotics pellagra, can also be used as vasodilators, a large number of food and feed additives. As a pharmaceutical intermediate for isoniazid,

ACIDUM-NICOTINICUM - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed.
UN IDs	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
RTECS	QT0525000
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	29362990
Toxicity	LD50 s.c. in rats: 5 g/kg (Brazda, Coulson)

ACIDUM-NICOTINICUM - Nature

Open Data Verified Data

White or opalescent crystalline powder, odorless or almost odorless, with a slightly sour taste. The melting point was 232-237 °c. Soluble in boiling water or ethanol, slightly soluble in water, almost insoluble in ether.

Last Update：2024-01-02 23:10:35

ACIDUM-NICOTINICUM - Preparation Method

Open Data Verified Data

nicotinic acid is initially obtained by the oxidation of nicotine, in the industry with alkyl pyridine, such as 3-methyl pyridine, 2 methyl -5-ethyl pyridine (MEP) and quinoline and the like are prepared as raw materials. From the synthesis method, generally divided into reagent oxidation, ammonia oxidation, gas phase oxidation, electrolytic oxidation and other methods.
nitric acid oxidation of MEP, 3 methyl pyridine or quinoline with nitric acid for liquid phase oxidation, nicotinic acid can be prepared. Gas phase oxidation method is characterized by air (or oxygen enriched air) as oxidant, under the action of Catalyst, the oxidation of 3 methyl pyridine in nicotinic acid. Anhui Chaoyang chemical plant used this method was put into production. This method because of the use of air as oxidant, catalyst can be used for a long time, and one-step oxidation in place, than ammonia oxidation less pollution, is a low cost, high efficiency, promising method.
potassium permanganate oxidation of 3 methyl pyridine as raw material, by potassium permanganate oxidation of nicotinic acid.
ammonia oxidation method 3-methylpyridine (or MEP) is subjected to gas-phase catalytic oxidation with air and ammonia to obtain nicotinonitrile; Further, nicotinonitrile is hydrolyzed to obtain nicotinamide or nicotinic acid.

Last Update：2022-01-01 10:10:42

ACIDUM-NICOTINICUM - Standard

Authoritative Data Verified Data

This product is pyridine +3-carboxylic acid. Calculated as dry product, the content of C6HsN 0 2 should be no less than 99.0% o

Last Update：2024-01-02 23:10:35

ACIDUM-NICOTINICUM - Trait

Authoritative Data Verified Data

This product is white crystal or crystalline powder; Odorless or slightly odorous, slightly sour; Acidic reaction in aqueous solution.
This product is dissolved in boiling water or boiling ethanol, slightly soluble in water, slightly soluble in ethanol, almost insoluble in ether; Soluble in sodium carbonate solution or sodium hydroxide solution.

Last Update：2022-01-01 11:24:46

ACIDUM-NICOTINICUM - Use

Open Data Verified Data

niacin is an essential nutrient for mammals.

Last Update：2022-01-01 10:10:42

ACIDUM-NICOTINICUM - Differential diagnosis

Authoritative Data Verified Data

take about 50mg of this product, add 2 0ml of water to dissolve, Dropwise add 0.4% sodium hydroxide solution until it shows neutral reaction in litmus paper. Add 3ml of copper sulfate test solution to slowly precipitate light blue precipitate.
take this product, add water to make a solution containing about 20 R per lm l, according to ultraviolet-visible spectrophotometry (General 0401), there is maximum absorption at the wavelength of 262nm, there is a minimum absorption at a wavelength of 237nm; The ratio of the absorbance at a wavelength of 237nm to the absorbance at a wavelength of 262NM should be 0. 35-0. 39.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 422).

Last Update：2022-01-01 11:24:46

ACIDUM-NICOTINICUM - Exam

Authoritative Data Verified Data

color of solution

take this product l.O g, Add 10ml of sodium hydroxide solution to dissolve: Check according to law (General rule 0901), if color, and the same volume of control solution (take 1.5 of cobalt chloride solution for color comparison), color with potassium dichromate solution 17ml and color with copper sulfate solution 1.5ml, add water to make 1000ml), not deeper.

3-cyanopyridine

take this product, precision weighing, adding ethanol to dissolve and dilute to make a solution containing about 10 mg per l lm as a test solution; Take an appropriate amount of 3-cyanopyridine reference substance, add ethanol to dissolve and dilute to make lm l containing about 0 .2M g of solution, as a control solution. According to the thin layer chromatography (General Rule 0 5 0 2) test, draw the Test Solution 4 0 ^ 1 and the reference solution 5M1, respectively, and point on the same silica gel G F 254 thin layer plate, with toluene-three gas methane-ethyl acetate-glacial acetic acid (7 .5 :5 :2:0.5) for the development of the agent, expand,, take out, dry, set the UV light (2 5 4 m n) under the inspection. If the test solution shows the impurity spots corresponding to the reference solution, the color of the test solution should not be deeper than the main spot of the reference solution (0.25).

chloride

take 0. 25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5. 0ml of standard sodium chloride solution, it should not be more concentrated (0.02%).

sulfate

take 0.50g of this product and check it according to law (General rule 0802). Compared with the control solution made of 1. 0ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).

loss on drying

take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure to constant weight. The weight loss shall not exceed 0831 (general rule).

ignition residue

The l .O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).

arsenic salt

take this product l.O g, add water 23ML and hydrochloric acid 5M l to dissolve, check according to law (General Principles 0822 first law), should comply with the provisions (0.0002%).

Last Update：2022-01-01 11:24:47

ACIDUM-NICOTINICUM - Content determination

Authoritative Data Verified Data

take about 0.3g of this product, weigh it accurately, add 50ml of fresh boiling cold water to dissolve, add 3 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide titration solution (0 .lmol/L). Each lm l sodium hydroxide titration solution (O .lm o l/L) corresponds to 12.31 mg of C6H5N02.

Last Update：2022-01-01 11:24:48

ACIDUM-NICOTINICUM - Category

Authoritative Data Verified Data

pharmaceutical excipients, cosolvents, carrier materials.

Last Update：2022-01-01 11:24:48

ACIDUM-NICOTINICUM - Storage

Authoritative Data Verified Data

sealed storage.

Last Update：2022-01-01 11:24:48

Changsha Changtang import and Export Co., Ltd.

ACIDUM-NICOTINICUM

Nicotinic acid

CAS: 59-67-6

Molecular Formula: C6H5NO2

ACIDUM-NICOTINICUM - Names and Identifiers

ACIDUM-NICOTINICUM - Physico-chemical Properties

ACIDUM-NICOTINICUM - Risk and Safety

ACIDUM-NICOTINICUM - Nature

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ACIDUM-NICOTINICUM - Preparation Method

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ACIDUM-NICOTINICUM - Standard

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ACIDUM-NICOTINICUM - Trait

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ACIDUM-NICOTINICUM - Use

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ACIDUM-NICOTINICUM - Differential diagnosis

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ACIDUM-NICOTINICUM - Exam

Authoritative Data Verified Data

color of solution

3-cyanopyridine

chloride

sulfate

loss on drying

ignition residue

Heavy metals

arsenic salt

ACIDUM-NICOTINICUM - Content determination

Authoritative Data Verified Data

ACIDUM-NICOTINICUM - Category

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ACIDUM-NICOTINICUM - Storage

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Supplier List

ACIDUM-NICOTINICUM Request for Quotation

Nicotinic acid

CAS: 59-67-6

Molecular Formula: C6H5NO2

ACIDUM-NICOTINICUM - Names and Identifiers

ACIDUM-NICOTINICUM - Physico-chemical Properties

ACIDUM-NICOTINICUM - Risk and Safety

ACIDUM-NICOTINICUM - Nature

Open Data Verified Data

ACIDUM-NICOTINICUM - Preparation Method

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ACIDUM-NICOTINICUM - Standard

Authoritative Data Verified Data

ACIDUM-NICOTINICUM - Trait

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ACIDUM-NICOTINICUM - Use

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ACIDUM-NICOTINICUM - Differential diagnosis

Authoritative Data Verified Data

ACIDUM-NICOTINICUM - Exam

Authoritative Data Verified Data

color of solution

3-cyanopyridine

chloride

sulfate

loss on drying

ignition residue

Heavy metals

arsenic salt

ACIDUM-NICOTINICUM - Content determination

Authoritative Data Verified Data

ACIDUM-NICOTINICUM - Category

Authoritative Data Verified Data

ACIDUM-NICOTINICUM - Storage

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Supplier List

ACIDUM-NICOTINICUM