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ATORVASTATIN

Atorvastatin

CAS: 134523-00-5;110862-48-1

Molecular Formula: C33H35FN2O5

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ATORVASTATIN - Names and Identifiers

Name Atorvastatin
Synonyms Atrovastitne
Atorvastatin
Atorvastatin Acid
ATORVASTATIN(LIPITOR)
Atorvastatin free ACID
1H-PYRROLE-1-HEPTANOIC ACID
Atorvastatin (Subject to Patent free)
(bR,dR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
(3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid
(3S,5S)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-2-(4-Fluorophenyl)-3,5-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-
CAS 134523-00-5
110862-48-1
EINECS 806-698-0
InChI InChI=1/C33H34FNO5.Ca/c1-21(2)31-30(33(40)24-11-7-4-8-12-24)29(22-9-5-3-6-10-22)32(23-13-15-25(34)16-14-23)35(31)18-17-26(36)19-27(37)20-28(38)39;/h3-16,21,26-27,36-37H,17-20H2,1-2H3,(H,38,39);/q;+2/p-1/t26-,27-;/m1./s1

ATORVASTATIN - Physico-chemical Properties

Molecular FormulaC33H35FN2O5
Molar Mass558.65
Density1.23±0.1 g/cm3(Predicted)
Melting Point176-178°C
Boling Point722.2±60.0 °C(Predicted)
pKapKa 4.46(H2O t=30 Iuncontrolled) (Uncertain)
Storage Condition2-8°C
Physical and Chemical PropertiesMelting point 176-178°C
UseUsed as hypolipidemic drug

ATORVASTATIN - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
HS Code35040000

ATORVASTATIN - Preparation Method

Open Data Verified Data

2-(4 fluorophenyl)-p carbonyl 8 hydroxy -5-(1-methyl ethyl)-3-phenyl 4 [(phenyl amino) carbonyl]-1H-pyrrole-1-heptanoic acid tert-butyl alcohol is reduced with triethylboron and sodium borohydride in methanol, and the product is hydrolyzed to obtain sodium atovastatin. Atovastatin is available via acidification. Atopastatin was refluxed in toluene to give atopastatin lactone.

Last Update：2024-01-02 23:10:35

ATORVASTATIN - Use

Open Data Verified Data

Pfizer co-launched with the company Parke-Davis and was launched in 19, 9, 7. Hypolipidemic drug. Can significantly reduce low density lipoprotein cholesterol and triglyceride levels. Can inhibit the activity of HMG-CoA reductase, thus reducing cholesterol synthesis.

Last Update：2022-01-01 09:11:01
ATORVASTATIN
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Shanghai Macklin Biochemical Co., Ltd
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsMultiple SpecificationsSpot supply
Product Name: 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Visit Supplier Webpage Request for quotation
CAS: 110862-48-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Atorvastatin Visit Supplier Webpage Request for quotation
CAS: 134523-00-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Multiple SpecificationsSpot supply
Product Name: Atorvastatin Visit Supplier Webpage Request for quotation
CAS: 110862-48-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Multiple SpecificationsSpot supply
Product Name: Atorvastatin Visit Supplier Webpage Request for quotation
CAS: 134523-00-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Atorvastatin Request for quotation
CAS: 134523-00-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
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View History
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