AZD0156
AZD0156
CAS: 1821428-35-6
Molecular Formula: C26H31N5O3
AZD0156 - Names and Identifiers
AZD0156 - Physico-chemical Properties
| Molecular Formula | C26H31N5O3 |
| Molar Mass | 461.56 |
| Density | 1.242±0.06 g/cm3(Predicted) |
| Boling Point | 628.3±55.0 °C(Predicted) |
| Solubility | DMSO: 6.2 mg/mL (Need ultrasonic and warming) |
| pKa | 9.27±0.28(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Azdo156 had an inhibitory effect on ATM in a cell experiment on the order of nanomolar, with more than 1000-fold higher selectivity for ATM than for other enzymes of the PIKK family. |
| In vivo study | Azdo156 is a cell-permeable, highly soluble compound with favorable preclinical pharmacokinetic properties (e. G., oral bioavailability). In the mouse xenograft tumor model, azdo156 and DSB inducer were administered by oral route with powerful efficacy. Azdo156 is currently in early clinical testing. |
AZD0156 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.167 ml | 10.833 ml | 21.666 ml |
| 5 mM | 0.433 ml | 2.167 ml | 4.333 ml |
| 10 mM | 0.217 ml | 1.083 ml | 2.167 ml |
| 5 mM | 0.043 ml | 0.217 ml | 0.433 ml |
Last Update：2024-01-02 23:10:35
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Product Name: AZD0156 Visit Supplier Webpage Request for quotationCAS: 1821428-35-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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