Autogramin-2 - Names and Identifiers
Autogramin-2 - Physico-chemical Properties
Molecular Formula | C21H27N3O4S
|
Molar Mass | 417.52 |
Density | 1.252±0.06 g/cm3(Predicted) |
Solubility | Soluble in DMSO |
Appearance | solid |
Color | Off-white |
pKa | 7.59±0.20(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Use | Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM). |
Autogramin-2 - Reference
Reference Show more | [1]. Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720. |
Autogramin-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.395 ml | 11.975 ml | 23.951 ml |
5 mM | 0.479 ml | 2.395 ml | 4.79 ml |
10 mM | 0.24 ml | 1.198 ml | 2.395 ml |
5 mM | 0.048 ml | 0.24 ml | 0.479 ml |
Last Update:2024-01-02 23:10:35
Autogramin-2 - Reference Information
biological activity | Autogramin-2 effectively inhibits starvation-induced autophagy with an IC50 of 0.27 μm. Autogramin-2 also inhibited the autophagy induced by Rapamycin (by inhibiting mTORC1) with an IC50 of 0.14 μm. |
Last Update:2024-04-10 22:29:15