C-PHYCOCYANIN
C-PHYCOCYANIN
CAS: 11016-15-2
Molecular Formula:
C-PHYCOCYANIN - Names and Identifiers
C-PHYCOCYANIN - Physico-chemical Properties
| Appearance | lyophilized powder |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Bioactive C- phycocyanin (C-PC) is a water-soluble protein pigment and is widely used as an excellent nutritional supplement for human beings. |
C-PHYCOCYANIN - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R32 - Contact with acids liberates very toxic gas R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 1687 6.1/PG 2 |
| WGK Germany | 1 |
| FLUKA BRAND F CODES | 10 |
C-PHYCOCYANIN - Uses and synthesis methods
natural nutrients
Phycocyanin is a blue pigment extracted from Spirulina and is a pure natural food pigment. Phycocyanin is one of the rare pigment proteins in nature. It is not only brightly colored, but also a nutritious protein and a good health food. It is the only natural blue pigment approved by FDA in the United States. The European Union has listed phycocyanin as a raw material for colored food, and its use in food is not restricted. China GB2760 Food Additives Catalogue also allows phycocyanin to be used as a natural colorant. Phycocyanin can also be used as medical and health products, cosmetics raw materials, biochemical reagents, etc.
application
The application research of phycocyanin is very common, and the following aspects can be summarized:
(1) natural food pigment: phycocyanin is a water-soluble pigment, pure blue, clear and lovely, and can be used as an additive for food colorants and cosmetics. And it is very rich in protein.
(2) medicine and health food: phycocyanin in vitro experiments proved that it has the effect of stimulating erythrocyte colony formation, similar to erythropoietin (EPO). Phycocyanin can help regulate and synthesize a variety of important enzymes needed by the human body. It plays an important role in inhibiting the growth of cancer cells. It can also regulate the human body's immune system, enhance the function of the immune system, and improve the body's resistance to diseases.
(3) cosmetics field: phycocyanin is a kind of collagen, with antioxidant, moisturizing, anti-allergic, freckle and other effects.
(4) special reagents for biology, chemistry and cytology experiments: phycocyanin blue and fluorescent, which can be used as some photodynamic research reagents for biology and cytology. It can also be used as a biochemical marker.
Isolation and purification of phycocyanin
freeze-thaw method: freeze the cells at low temperature for a certain period of time, then take them out and melt them at room temperature. Such repeated freezing and thawing for many times can cause swelling and fragmentation of cells while forming ice particles and increasing the concentration of remaining cytosolic salts.
Salting-out method: The positive and negative ions formed by the ionization of salt in the aqueous solution can attract water molecules, thereby destroying the water film of the protein, neutralizing part of the charge, causing the protein to aggregate and precipitate and precipitate from the solution. Due to the difference in the size of various protein particles, the amount of charge and the degree of hydrophilicity, when a certain neutral salt is used for salting out, the minimum salt concentration required is different.
DEAE cellulose: English name DEAE-Cellulose, diethylamine ethyl cellulose, total exchange capacity 0.9meq/g functional group: diethylamine ethyl weakly basic anion exchanger. Principle: Contains certain functional groups, which can be ion exchanged. The performance is milder than that of general ion exchange resins, which is suitable for separating macromolecules with biological activity, and can separate macromolecular substances with similar properties.
Food grade phycocyanin
Phycocyanin is an active protein isolated and purified from cyanobacteria. It is a rare scarp pigment protein. It is a natural edible pigment allowed by the country. More importantly, studies have shown that phycocyanin can significantly reduce tumor radiation The damage to normal white blood cells in the human body during chemotherapy stimulates the colony of red blood cells and platelets, improves immunity, and protects liver tissue. It has unique fluorescence properties and good biological efficacy. It has the same properties as protein. The product is blue particles or powder. Soluble in water. Insoluble in alcohol and grease. Organic solvents such as ethanol can cause irreversible denaturation of phycocyanin. The color of its aqueous solution is bright blue. Each phycocyanin monomer consists of a subunit and B subunit. its monomer (AB) has a molecular weight of about 40,000 d, a trisomal (AB) at pH6.5-8.0, and a hexasomal (AB) at pH4.5-6.0, with a molecular weight of about 230,000 d. No matter in the form of monomer, three-body or six-body, it presents a beautiful sapphire color under visible light, and its color is bright. It is quite stable under various physical and chemical factors.
Last Update：2024-04-09 18:58:34
C-PHYCOCYANIN - Uses and synthesis methods
In vitro studies
For the combination experiments, when cells treated with All-trans retinoic acid (ATRA) combined with C- phycocyanin, the IC 50 value is lower than that in ATRA group. But under the same IC 50 , the more C- phycocyanin is used, the less ATRA is needed. Results demonstrate that C- phycocyanin combined with ATRA can significantly decrease CDK-4 mRNA level (P<0.05). The combination index (CI) value of the C- phycocyanin ATRA combination group is 0.852 which is less than 1, indicating that the two drugs are synergetic under the action concentration (88 μg/L C- phycocyanin 0.102 mM ATRA). Compare with control group, the Integrated optical density (IOD) in C- phycocyanin or ATRA treated group is increased, and the differences are statistically significant (P<0.05) and the differences are further exaggerated in combination group (P<0.01). The expression of caspase-3 in C- phycocyanin group is more than that in the control group but is similar to that in ATRA group, whereas the expression in combination group is maximum.
In vivo studies
Compare with control group, the average tumor weights of mice in solely C- phycocyanin or ATRA treatment groups are significantly decreased, and further reduced in C- phycocyanin ATRA synergy group. Results show that single C- phycocyanin can increase the spleen weight of mice but the effects of ATRA are just opposite. C- phycocyanin can also promote the growth of immune organs in mice and increase the body's immune function. C- phycocyanin and ATRA alone can significantly inhibit Cyclin D1 expression, and when being combined, the inhibitory effect is more obvious.
Last Update：2024-04-09 20:52:54
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Product Name: C-PHYCOCYANIN Visit Supplier Webpage Request for quotation
CAS: 11016-15-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 11016-15-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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