CS-425
Droxinostat
CAS: 99873-43-5
Molecular Formula: C11H14ClNO3
CS-425 - Names and Identifiers
CS-425 - Physico-chemical Properties
| Molecular Formula | C11H14ClNO3 |
| Molar Mass | 243.69 |
| Density | 1.252 |
| Solubility | DMSO: ≥20mg/mL |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD01326592 |
| Use | Droxinostat |
| In vitro study | Droxinostat was initially used as a sensitizer for FAS and TRAIL in PPC-1 cells by down-regulating the interleukin-1-like converting enzyme inhibitor protein (c-Fas), which is the region of death associated with c-FLIP. 20 μm -60 μm Droxinostat acts on PPC-1 cells in suspension culture, by first activating caspase 8 and then activating the mitochondrial pathway, which makes the cells more susceptible to apoptosis. Droxinostat also made other cancer cell lines including PC-3, DU-145, T47D, and OVCAR-3, but not LNCaP and MB-MDA-468, more susceptible to anodyne apoptosis, or CH-11-induced apoptosis. However, until now the direct target of Droxinostat has not been discovered. Droxinostat was found to selectively inhibit HDAC3, 6, and 8 in the histone acetylase (HDAC) 1-10 subtype, with IC50 values of 16.9 μm, 2.47 μm, and 1.46 μm, respectively, however, the effect on other HDAC members was not obvious, IC50 > 20 μm. 10 μM-100 μm Droxinostat acts on MCF-7 breast cancer cells to reduce cell survival and induce apoptosis by reducing the expression of c-FLIP L and c-FLIP S, making the cells more susceptible to apoptosis. |
| In vivo study | The SCID mouse model carrying PPC-1 cells was treated with 30 μm Droxinostat to act on PPC-1 cells to reduce tumor formation. |
CS-425 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
CS-425 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.104 ml | 20.518 ml | 41.036 ml |
| 5 mM | 0.821 ml | 4.104 ml | 8.207 ml |
| 10 mM | 0.41 ml | 2.052 ml | 4.104 ml |
| 5 mM | 0.082 ml | 0.41 ml | 0.821 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Droxinostat Visit Supplier Webpage Request for quotationCAS: 99873-43-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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