Chalkone
PHENYL STYRYL KETONE
CAS: 94-41-7
Molecular Formula: C15H12O
Chalkone - Names and Identifiers
Chalkone - Physico-chemical Properties
| Molecular Formula | C15H12O |
| Molar Mass | 208.26 |
| Density | d462 1.0712 |
| Melting Point | 55-59°C |
| Boling Point | 208°C25mm Hg(lit.) |
| Flash Point | >230°F |
| Solubility | dioxane: soluble1g/10 mL, clear, colorless |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Granular Powder |
| Color | Yellow |
| Merck | 14,2037 |
| BRN | 1210466 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | nD62 1.6458 |
| Physical and Chemical Properties | Light yellow orthorhombic or prismatic crystals. Melting point 57-58 ℃, boiling point 345-348 ℃ (microdecomposition), relative density 1.0712(62/4 ℃), refractive index (nD62)1.6458, soluble in ether, chloroform, carbon disulfide and benzene, slightly soluble in alcohol, hardly soluble in cold petroleum ether. |
| In vitro study | Chalcone derivatives are synthesized by Claisen-Shimidt base-catalyzed condensation of appropriate aromatic ketones or substituted aromatic ketones with benzaldehydes or substituted benzaldehydes. |
Chalkone - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37 - Irritating to eyes and respiratory system. |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | UD5576750 |
| HS Code | 29143900 |
Chalkone - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | chalcone belongs to flavonoids of phenolic compounds. They form one of the largest group of biologically active natural products. The potential anti-cancer, anti-inflammatory, anti-bacterial, anti-oxidant and anti-parasitic properties of naturally occurring chalcone and its unique chemical structure characteristics have stimulated the synthesis of numerous chalcone derivatives. |
| preparation | chalcone can be prepared by aldol condensation reaction of benzaldehyde and acetophenone catalyzed by sodium hydroxide. It has been found that the reaction can also be carried out in the absence of any solvent and is a solid reaction. The reaction of benzaldehyde derivatives and acetophenone has become a part of Green Chemistry in undergraduate chemistry education. In a study of green chemistry, it was found that chalcones can also be synthesized from the same starting materials in warm water (200-350°C). In addition, chalcone derivatives are synthesized by piperidine-mediated condensation to avoid side reactions such as multiple condensation, polymerization and rearrangement. |
| Use | phenylstyrone is a chalcone compound, which is an important organic synthesis intermediate for the synthesis of a variety of drugs. used in organic synthesis, such as sweeteners. |
| biological activity | Chalcone (benzylideneacrophone, phenyl styryl ketone, benzalacrophone, β-phenylacryophone) is an aromatic ketone, it is the center of many important biological compounds (chalcones) with antibacterial, antitumor and anti-inflammatory activities. |
| production method | a mixture of sodium hydroxide solution and ethanol is cooled, vigorously stirred, and freshly distilled acetophenone and benzaldehyde are added, after stirring at 15-30 ° C. For 2-3H, the reactant was gradually thickened, the frozen solution was allowed to stand, yellow precipitate was precipitated, filtered, washed to neutral, and recrystallized with ethanol to obtain chalcone, with a yield of 84%. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD: > 500 mg/kg 'abdominal-mouse LD50: 200 mg/kg |
| flammability hazard characteristics | in case of open flame, heat, flammable oxidant; Thermal decomposition of spicy stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate from oxidant |
| fire extinguishing agent | carbon dioxide, foam, dry powder |
Last Update：2024-04-09 02:00:12
Supplier List
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: PHENYL STYRYL KETONE Request for quotation
CAS: 94-41-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 94-41-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: 1,3-Diphenyl-1-propen-3-one Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: PHENYL STYRYL KETONE Request for quotation
CAS: 94-41-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 94-41-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: 1,3-Diphenyl-1-propen-3-one Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Chalcone Visit Supplier Webpage Request for quotationCAS: 94-41-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Chalkone
Trichloroacetic anhydride
Kayarad DEGDA
2-hydroxy-4,6-dipropoxybenzaldehyde
正硅酸锂
科立内酯
Pyrimidine, 2-nitro-4,6-diphenyl-
Benz[h]isoquinoline
Trichloroacetic anhydride
Kayarad DEGDA
2-hydroxy-4,6-dipropoxybenzaldehyde
正硅酸锂
科立内酯
Pyrimidine, 2-nitro-4,6-diphenyl-
Benz[h]isoquinoline