Molecular Formula | C18H39NO2 |
Molar Mass | 301.51 |
Density | 0.927±0.06 g/cm3(Predicted) |
Melting Point | 70-72°C |
Boling Point | 446.2±25.0 °C(Predicted) |
Solubility | DMSO: soluble25mg/mL (warm) |
Appearance | White to off-white solid. |
Color | white |
pKa | 12.57±0.45(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
In vitro study | D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na 3 VO 4 -, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [ 3 H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA 2 α activity. |
WGK Germany | 3 |
biological activity | D-Erythro-dihydrosphingosin directly inhibits phospholipase A2α (cPLA2α) activity in the cytosol. |