DBCO-NHCO-PEG4-acid - Names and Identifiers
DBCO-NHCO-PEG4-acid - Physico-chemical Properties
| Molecular Formula | C32H40N2O9
|
| Molar Mass | 596.67 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Boling Point | 855.9±65.0 °C(Predicted) |
| pKa | 4.28±0.10(Predicted) |
| Storage Condition | 2-8°C，干燥，密封 |
| MDL | MFCD28334546 |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
DBCO-NHCO-PEG4-acid - Reference Information
| biological activity | DBCO-Amide-PEG5-acid is a PROTAC Bridge belonging to the PEG class. DBCO-Amide-PEG5-acid can be used to synthesize a range of PROTAC molecules. DBCO-Amide-PEG5-acid is a cleavable ADC Bridge for the synthesis of antibody drug conjugates (ADCs). |
| Target | Cleavable PEGs |
| in vitro study | PROTACs contains two different ligans connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intrinsic ubiquitin-proteasome system to selective grade target proteins. ADCs are assembled of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-09 21:01:54
