DIOSCIN
Dioscin
CAS: 19057-60-4
Molecular Formula: C45H72O16
DIOSCIN - Names and Identifiers
| Name | Dioscin |
| Synonyms | DIOSCIN Dioscin dioscine DIOSCIN(P) collettisideiii Dioscin(Collettiside III) yranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl)-(1-4))- beta-d-glucopyranoside,(3-beta,25r)-spirost-5-en-3-ylo-6-deoxy-alpha-l-mannop β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- |
| CAS | 19057-60-4 |
| InChI | InChI=1/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27?,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1 |
DIOSCIN - Physico-chemical Properties
| Molecular Formula | C45H72O16 |
| Molar Mass | 869.06 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 275～277℃ |
| Specific Rotation(α) | D13 -115° (c = 0.373 in ethanol) |
| Solubility | Insoluble in water, petroleum ether, benzene, soluble in methanol, ethanol, acetic acid, slightly soluble in acetone, pentanol |
| Appearance | White or yellowish crystalline powder |
| Color | White to Off-White |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.613 |
| MDL | MFCD02094174 |
| Physical and Chemical Properties | Insoluble in water, petroleum ether, benzene, soluble in methanol, ethanol, acetic acid, acetone-soluble, pentanol. Rhizome derived from Dioscorea nipponica Makino |
DIOSCIN - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
DIOSCIN - Reference Information
| basic information | extraction source: dioscoreaceae plant wearing dioscorea DioscoreaNipponica physical properties: white powder risk term: skin irritation, serious damage to eyes solubility: diosgenin is insoluble in water, petroleum ether, benzene, soluble in methanol, ethanol, acetic acid, slightly soluble in acetone and pentanol optical rotation: -115 (C = 0.373, ethanol) product melting point: 294~296 ℃ determination method: high performance liquid chromatography storage conditions: 4 ℃ cold storage, sealing, light protection |
| overview | dioscin is the main ingredient in Dioscoreaceae plants. Traditional Chinese medicine believes that Dioscorea zingiberensis has the effects of expectorant, digestion and diuresis, relaxing muscles and promoting blood circulation, and cutting malaria. Modern pharmacological studies have shown that dioscin has many pharmacological effects, especially in anti-tumor effects. Many studies have also shown that dioscin can improve atherosclerosis symptoms and protect vascular endothelial function, reduce ischemia/reperfusion injury of heart, brain and kidney, reduce blood sugar, inhibit liver fibrosis, improve menopausal osteoporosis, relieve rheumatoid arthritis and ulcerative colitis, antagonize bacteria and virus activity. This article reviews the recent research reports on the modern pharmacology of dioscin [2]. |
| pharmacological effects | dioscin has anti-tumor, anti-thrombosis, anti-allergy, anti-virus and anti-shock effects. It has anti-inflammatory, anti-tumor, anti-virus, lowering cholesterol, lowering blood pressure, killing mollusks, anti-fertility and other effects. It can be used for the treatment of tracheitis. It has the effect of killing insects and resisting fungi such as Trichomonas. The peroxidolytic enzyme contained in it has obvious anti-aging effect. Long-term service can remove scars on the face and make the skin tender and smooth. It can be used as a raw material for the synthesis of steroid hormones and contraceptives. |
| pharmacological effects | modern pharmacological studies show that dioscin has many pharmacological effects, especially in anti-tumor effects. In addition, many studies have also shown that dioscin can improve atherosclerosis symptoms and protect vascular endothelial function, reduce ischemia/reperfusion (I /R) injury of heart, brain and kidney, reduce blood sugar, inhibit liver fibrosis, improve menopausal osteoporosis, relieve rheumatoid arthritis and ulcerative colitis, antagonize bacteria and virus activity. |
| anticancer mechanism | studies have shown that dioscin can participate in many biological processes such as cell process, metabolic process, biological regulation, stress response, signal pathway and cell proliferation, so that dioscin can intervene in the life process of cancer cells to achieve anticancer effect. Studies have confirmed that dioscin can play an anti-tumor role in inducing tumor cell differentiation and apoptosis, enhancing the expression of tumor suppressor genes, regulating cell cycle, inhibiting tumor cell division and proliferation, etc. The anti-cancer mechanism of dioscin is multi-point effect, and each part is closely connected. At present, the research on the anti-cancer mechanism in the research field is not detailed enough, but with the further research of molecular biology, the understanding of this mechanism will be more comprehensive and thorough. Dioscin is a very good natural medicine, and its hydrolysate diosgenin is also an important synthetic material for many steroid hormones. In addition to anti-cancer and some biological activities, dioscin also has the effect of treating liver fibrosis. These functions prove that dioscin has broad research prospects. With the deepening of research, the medicinal value of dioscin will be gradually developed, showing a good application prospect. |
| application in liver protection pharmaceutical preparations | the invention discloses the application of dioscin in the preparation of liver protection pharmaceutical preparations, which can significantly inhibit the increase of transaminase and lactate dehydrogenase activities caused by drugs (carbon tetrachloride or paracetamol) and alcohol, reduce liver index and exert its liver protection effect; the invention can also increase SOD activity and reduce MDA content, increase the content of GSH, inhibit the drug (carbon tetrachloride or paracetamol) induced liver lipid peroxidation; At the same time, the present invention can also reduce the content of TG and TC, inhibit the liver steatosis caused by alcohol. Dioscin can be used as raw material, according to the relevant requirements of pharmacy and clinical needs to make various dosage forms for clinical application, such as: tablets, capsules, injections, oral liquid preparations, granules, etc., with safety (non-toxic and no side effects), simple, economical and other advantages. |
| preparation of dioscin tablets | 100g of dioscin, 125g of starch, 175g of lactose and 100g of microcrystalline cellulose were used as raw materials. pass the above main medicine and auxiliary materials through 80 mesh sieve respectively, mix them thoroughly and evenly, use 5% povidone K30(PVPK30) ethanol solution as binder, granulate with 20 mesh sieve, dry at 40?60°C, complete with 18 mesh sieve, and add appropriate amount of lubricant to tablet, each tablet is 0.5g. Figure 1 Dioscin Tablets |
| references | [1] dioscin. Bailian Database. [Citation Date 2017.09.09] [2] [Journal Papers] Wang Shurong, Ling Shuang, Zhang Qingguang, Xu Jinwen, WANG Shu-rong, LING Shuang, ZHANG Qing-guang, XU Jin-wen-Chinese Pharmacological Bulletin 2017 Issue 2 [3] [Journal Papers] Zhang Ziwei, Li Ying, Cao Peng, Li Xiaoyan, ZHANG Ziwei, LI Ying, CAO Peng, LI Xiaoyan-Food Science 2017 Issue 1 [4] Peng Jinyong, Sun Changkai, Lu Binan, Zheng Lingli, Liu Kexin, Li Zhen, Xu Lina, Han Xu, Yin Lianhong, Xu Youwei, Qi Yan, Liu Yuetao. Application of Dioscin in Preparation of Liver Protection Drug Preparation [P]. Liaoning: CN101837004A,2010-09-22. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-inflammatory, anti-tumor, anti-virus, lowering cholesterol, lowering blood pressure, killing molluscs, anti-fertility and other effects. It can be used for the treatment of tracheitis. It has the effect of killing insects and resisting fungi such as Trichomonas. The peroxidolytic enzyme contained in it has obvious anti-aging effect. Long-term service can remove scars on the face and make the skin tender and smooth. It can be used as a raw material for the synthesis of steroid hormones and contraceptives. |
Last Update：2024-04-09 21:21:28
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Featured ProductsSpot supply
Product Name: Dioscin Visit Supplier Webpage Request for quotationCAS: 19057-60-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Dioscin Visit Supplier Webpage Request for quotationCAS: 19057-60-4
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
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