Delamanid

Name	Delamanid
Synonyms	Delamanid OPC-67683 (2R)-2-METHYL-6-NITRO-2-[[4-[4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDIN-1-YL]PHENOXY]METHYL]-3H-IMIDAZO[2,1-B][1,3]OXAZOLE (R)-2-Methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo[2,1-b]oxazole (2R)-2,3-Dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]imidazo[2,1-b]oxazole
CAS	681492-22-8

Molecular Formula	C25H25F3N4O6
Molar Mass	534.48
Density	1.45
Melting Point	195-196℃
Boling Point	653.7±65.0 °C(Predicted)
Solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly, Sonicated)
Appearance	Solid
Color	Off-White to Light Yellow
pKa	3.99±0.20(Predicted)
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere
Stability	Hygroscopic
Physical and Chemical Properties	The biological activity of Delamanid (OPC-67683) is a new type of anti-tuberculosis drug, which has good intracellular bactericidal activity and high accumulation rate in cells.
In vitro study	Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis. Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration.
In vivo study	Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL.

Last Update：2024-01-02 23:10:35

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QQ: 3008007409

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Delamanid

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