OPC-67683 MedChemExpress (MCE)

Product Name	Delamanid
Synonyms	Delamanid OPC-67683 (2R)-2-METHYL-6-NITRO-2-[[4-[4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDIN-1-YL]PHENOXY]METHYL]-3H-IMIDAZO[2,1-B][1,3]OXAZOLE (R)-2-Methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo[2,1-b]oxazole Synonyms Delamanid OPC-67683 (2R)-2-METHYL-6-NITRO-2-[[4-[4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDIN-1-YL]PHENOXY]METHYL]-3H-IMIDAZO[2,1-B][1,3]OXAZOLE (R)-2-Methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo[2,1-b]oxazole (2R)-2,3-Dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]imidazo[2,1-b]oxazole
CAS	681492-22-8
EINECS
Chemical Formula	C25H25F3N4O6
Molecular Weight	534.48
inchi
Package	10 mM * 1 mL;1 mg;2 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Delamanid Delamanid MedChemExpress (MCE) HY-10846 681492-22-8 OPC-67683 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Delamanid Delamanid MedChemExpress (MCE) HY-10846 681492-22-8 OPC-67683 99.96% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids. Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex[1]. Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis[2]. Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration[3]. Delamanid (orally administration 30 mg/kg 5 days) results in sterile cures in a mouse model of VL[4]. \| \| \| \| \| \| \| \| \| \| [1]. Sotgiu G et al. Delamanid (OPC-67683) for treatment of multi-drug-resistant tuberculosis. Expert Rev Anti Infect Ther. 2015 Mar 13(3):305-15. [Content Brief] [2]. Xavier AS et al. Delamanid: A new armor in combating drug-resistant tuberculosis. J Pharmacol Pharmacother. 2014 Jul 5(3):222-4 [Content Brief] [3]. Mallikaarjun S et al. Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects. Antimicrob Agents Chemother. 2016 Sep 23 60(10):5976-85. [Content Brief] [4]. Patterson S et al.The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis. Elife. 2016 May 24 5. [Content Brief]
Last Update	2025-04-01 14:45:47

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