FELODIPINE
FELODIPINE
CAS: 72509-76-3;86189-69-7
Molecular Formula: C18H19Cl2NO4
FELODIPINE - Names and Identifiers
| Name | FELODIPINE |
| Synonyms | Spendil CGH-869 FELODIPINE ,ethylmethylester ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester |
| CAS | 72509-76-3 86189-69-7 |
| EINECS | 620-472-7 |
| InChI | InChI=1/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 |
| InChIKey | RZTAMFZIAATZDJ-UHFFFAOYSA-N |
FELODIPINE - Physico-chemical Properties
| Molecular Formula | C18H19Cl2NO4 |
| Molar Mass | 384.25 |
| Density | 1.3506 (rough estimate) |
| Melting Point | 142-145°C |
| Boling Point | 471.5±45.0 °C(Predicted) |
| Flash Point | 239°C |
| Water Solubility | insoluble |
| Solubility | DMSO: soluble28 mg/mL H2O: insoluble |
| Vapor Presure | 4.62E-09mmHg at 25°C |
| Appearance | White or yellowish crystalline powder |
| Color | light yellow |
| pKa | 2.73±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00868316 |
| Physical and Chemical Properties | Melting point 142-145°C water-soluble insoluble |
| Use | For the treatment of hypertension, ischemic heart disease, heart failure and other diseases |
FELODIPINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | US7968700 |
| HS Code | 29333990 |
FELODIPINE - Standard
Authoritative Data Verified Data
This product is (±)-2, 6-dimethyl-4-(2, 3-dichlorophenyl)-l, 4-dihydro-3, methyl Ethyl 5-pyridinedicarboxylate. Calculated as dried product, the content of C18H19C12N04 shall not be less than 99.0%.
Last Update：2024-01-02 23:10:35
FELODIPINE - Trait
Authoritative Data Verified Data
- This product is white to light yellow crystal or crystalline powder; Odorless; Unstable in light.
- This product is soluble in acetone, methanol or ethanol, almost insoluble in water.
melting point
The melting point of this product (General 0612) is 141~145°C.
Last Update：2022-01-01 13:35:06
FELODIPINE - Differential diagnosis
Authoritative Data Verified Data
- Take 20mg of this product, add 1 ml of hydrochloric acid to dissolve, add 1 ml of hydroxylamine hydrochloride test solution, mix well, Dropwise add 20% sodium hydroxide solution to make it alkaline, boil in water bath for 30 minutes, and let it cool, then, 1 mol/ L hydrochloric acid solution was added dropwise to make it acidic. After adding several drops of ferric chloride solution, the solution was reddish brown in color.
- take this product, dissolve and dilute with ethanol to make a solution containing 20ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at wavelengths of 238nm and 361NM.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 794).
Last Update：2022-01-01 13:35:06
FELODIPINE - Exam
Authoritative Data Verified Data
clarity and color of methanol solution
take this product l. After being dissolved by adding 20ml of methanol, the solution shall be clear and colorless; If the color is colored, it shall be checked according to law (General rule 0901 second method), and the absorbance shall be measured at the wavelength of 440nm, and shall not exceed 0.10.
chloride
take 2.0g of this product, add 50ml of water, boil, immediately cool, add water to make up 50ml, filter, take 25ml of filtrate, check according to law (General rule 0801), not more concentrated (0.005%) than the control solution made from of standard sodium chloride solution.
Related substances
operation in the dark. Take this product, precision weighing, add methanol to dissolve and quantitatively dilute to make a solution containing about 1 mg per 1 ml, as a test solution; Take another 2, 6-dimethyl-4-(2,3-dichlorophenyl)-3, 5-pyridinedicarboxylic acid methyl ester (impurity I ), Precision weighing, plus methanol dissolved and quantitative dilution made in each 1 ml containing about 0.1 mg of the solution, take 1 ml accurately, put it in a 100ml measuring flask, add 1 ml of the test solution accurately, dilute to the scale with the mobile phase, shake well, and use as a control solution. According to high performance liquid chromatography (General 0512) test. Silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-acetonitrile-water (50:15:35) was used as the mobile phase; The detection wavelength was 238nm. Take appropriate amount of Felodipine and impurity I control, add methanol to dissolve and dilute to make mixed solution containing about 1 mg and 10ug respectively per 1 ml, take 10 u1, inject human liquid chromatograph, the degree of separation of the impurity I peak from the Felodipine peak should be greater than 3.0. The LOLs of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there is a chromatographic peak in the chromatogram of the test solution that is consistent with the retention time of impurity I, the peak area shall be calculated according to the external standard method, and shall not exceed 0.1%; the Peak area of other individual impurities shall not be greater than 0.5 times (0.5%) The Peak area of Felodipine in the control solution; The total amount of impurities shall not exceed 1.0%.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take 1.0g of this product and check it according to law (General rule 0841). The remaining residue shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product l.Og, add lg mixed with calcium hydroxide, add a small amount of water, stir evenly, first heat with small fire, then burn to complete Ash, gray-white, cool, the residue shall be dissolved by adding 8ml of hydrochloric acid and 20ml of water, and shall be checked according to law (General Principles 0822, first law), and shall comply with the regulations (0.0002%).
Last Update：2022-01-01 13:35:07
FELODIPINE - Content determination
Authoritative Data Verified Data
take this product 0.3g, precision weighing, add glacial acetic acid 40ml dissolved, add dilute sulfuric acid 20ml and O-Phenanthroline indicator solution 2 drops, with cerium sulfate titration solution (O. 1 mol/L) titration to Orange disappeared, and the titration results were corrected with a blank test. Each 1 ml of the cerium sulfate titration solution (0.1 mol/L) corresponds to 19.21mg of C18H19Cl2NO4.
Last Update：2022-01-01 13:35:07
FELODIPINE - Category
Authoritative Data Verified Data
calcium channel blockers.
Last Update：2022-01-01 13:35:07
FELODIPINE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:35:08
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Featured ProductsMultiple SpecificationsSpot supply
Product Name: Felodipine Visit Supplier Webpage Request for quotationCAS: 86189-69-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Felodipine Visit Supplier Webpage Request for quotationCAS: 72509-76-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Felodipine Visit Supplier Webpage Request for quotationCAS: 72509-76-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Felodipine Visit Supplier Webpage Request for quotationCAS: 86189-69-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
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Product Name: Felodipine Visit Supplier Webpage Request for quotationCAS: 86189-69-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Tel: 18301782025
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View History
FELODIPINE
Methyl thiocyanate
Amlodipine Impurity 26
Phosphoric acid, bis(4-nitrophenyl) ester
(3R,5R)-5-三氟甲基哌啶-3-醇
2- Methyl-4-broMo benzoic acidMethyl ester
Leaf acetate
2,6-Dinitrofenol [Czech]
Methyl thiocyanate
Amlodipine Impurity 26
Phosphoric acid, bis(4-nitrophenyl) ester
(3R,5R)-5-三氟甲基哌啶-3-醇
2- Methyl-4-broMo benzoic acidMethyl ester
Leaf acetate
2,6-Dinitrofenol [Czech]