Name | vindesine sulfate |
Synonyms | Fildesi Elsedine LY-099094 vindesine sulfate vindesine sulphate VINCRISITINESULFATE VINDESINE SULFATE SALT Desacetylvinblastine amide sulfate salt |
CAS | 59917-39-4 |
EINECS | 261-984-7 |
InChI | InChI=1/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4)/t25-,34+,35-,36-,39+,40-,41-,42+,43+;/m1./s1 |
Molecular Formula | C43H57N5O11S |
Molar Mass | 852 |
Melting Point | >2500C |
Solubility | deionized water: ≥50mg/mL |
Appearance | White-like powder |
Color | off-white to light yellow |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
MDL | MFCD01675266 |
Hazard Symbols | Xn - Harmful![]() |
Risk Codes | 40 - Limited evidence of a carcinogenic effect |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | YY8090000 |
Hazard Class | 6.1(a) |
Packing Group | II |
Toxicity | LD50 in mice, rats (mg/kg): 6.3 ± 0.6, 2.0 ± 0.2 i.v. (Todd); in mice: 8.8 ± 2.5 i.p. (Owellen, Biochem. Pharmacol.) |
biological activity | Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, desacetylblastine amide, DAVA, DVA, VDS) it is a vinca alkaloid extracted from Catharanthus roseus, is a potent inhibitor of mitosis mitosis, and has anti-tumor activity. Vindesine binds to tubulin of the mitotic spindle and can lead to microtubule crystallization and mitotic arrest or cell death. |
Use | anticancer drug. an inhibitor of tubulin. |