HOOC-PEG-COOH

HOOC-PEG-COOH - Names and Identifiers

Name	HOOC-PEG-COOH
Synonyms	HOOC-PEG-COOH Bis-PEG25-acid COOH-PEG8-COOH Bis-PEG10-acid HOOC-PEG8-COOH HOOCCH2CH2-PEG24-CH2CH2COOH HOOCCH2CH2O-PEG8-CH2CH2COOH α,ω-dipropionic acid octaethylene glycol
CAS	1268488-70-5

HOOC-PEG-COOH - Physico-chemical Properties

Molecular Formula	C22H42O13
Molar Mass	514.56
Density	1.174±0.06 g/cm3(Predicted)
Boling Point	630.0±55.0 °C(Predicted)
pKa	3.97±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

HOOC-PEG-COOH - Reference Information

biological activity

Bis-peg9-acid is a PROTAC linker belonging to the PEG class. Bis-peg9-acid can be used to synthesize a range of PROTAC molecules. Bis-peg9-acid is a cleavable ADC linker for the synthesis of antibody-conjugated drugs (ADCs).

Last Update：2024-04-10 22:43:14