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IR-125

Indocyanine Green

CAS: 3599-32-4

Molecular Formula: C43H49N2NaO6S2

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IR-125 - Names and Identifiers

Name Indocyanine Green
Synonyms
IR-125
UJOVIRIDIN
Sodium 2-(7-(3
5-trien-1-yl)-3
Indocyanine Green
Cardiogreen, Foxgreen, IR-125
Foxgreen, IC Green, Indocyanine green
3-dimethyl-1-(4-sulfonatobutyl)benz[e]indolinium
3-dimethyl-1-(4-sulfonatobutyl)benz(e)indolin-2-ylidene)hepta-1
4-[(2Z)-2-[(2Z,4E,6Z)-7-[3,3-dimethyl-1-(4-sulfonatobutyl)benzo[g]indol-1-ium-2-yl]hepta-2,4,6-trienylidene]-3,3-dimethyl-benzo[g]indol-1-yl]butylsulfonyloxysodium
sodium 4-(2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indolium-2-yl]hepta-2,4,6-trien-1-ylidene}-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)butane-1-sulfonate
CAS 3599-32-4
EINECS 222-751-5
InChI InChI=1/C43H48N2O6S2.Na/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-52(46,47)48)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1/rC43H47N2NaO6S2/c1-42(2)36-26-24-32-18-10-12-20-34(32)40(36)44(28-14-16-30-53(47,48)49)38(42)22-8-6-5-7-9-23-39-43(3,4)37-27-25-33-19-11-13-21-35(33)41(37)45(39)29-15-17-31-54(50,51)52-46/h5-13,18-27H,14-17,28-31H2,1-4H3

IR-125 - Physico-chemical Properties

Molecular FormulaC43H49N2NaO6S2
Molar Mass776.98
Melting Point235 °C
Water Solubilityslightly soluble
Solubility H2O: soluble1mg/mL
AppearancePowder
ColorGreen-bronze
Merck14,4962
BRN4115884
Storage ConditionKeep in dark place,Inert atmosphere,Room temperature
SensitiveSensitive to light and easy to absorb moisture
MDLMFCD00013078
UseLiver function determination diagnostic medication, IR laser dye.
In vitro study Cardiogreen-photodynamic therapy (ICG-PDT) at concentrations 1000 μg/mL, induces the significant expression of BAX in HGF cells; however, the laser irradiation as well as ICG shows no significant effects on the expression of BCL-2 gene.

IR-125 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany3
RTECSDE3150000
HS Code32129000
ToxicityLD50 intravenous in mouse: 60mg/kg

IR-125 - Reference

Reference
Show more
1. [IF=12.479] Jian Chen et al."A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy."Biomaterials. 2021 Jan;266:120457
2. [IF=6.419] Lili Ren et al."RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor."Drug Deliv. 2021;28(1):2024-2032
3. [IF=4.617] Jiang Linxia et al."A dry powder inhalable formulation of salvianolic acids for the treatment of pulmonary fibrosis: safety, lung deposition, and pharmacokinetic study."Drug Deliv Transl Re. 2021 Oct;11(5):1958-1968
4. [IF=3.882] Chenghao Liu et al.Pressure-Controlled Encapsulation of Graphene Quantum Dots into Liposomes by the Reverse-Phase Evaporation Method.Langmuir. 2021;37(48):14096–14104
5. [IF=6.4] Yichi Chen et al."RNA-Seq Explores the Mechanism of Oxygen-Boosted Sonodynamic Therapy Based on All-in-One Nanobubbles to Enhance Ferroptosis for the Treatment of HCC."Int J Nanomed. 2022; 17: 105–123
6. [IF=6.843] Pei-Ying Huang et al."Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity."Biomater Sci-Uk. 2022 Jan;:

IR-125 - Standard

Authoritative Data Verified Data

This product is 2-[7-[l, l-dimethyl-3-(4-sulfobutyl)] benzoindolyl)-l,3, 5-heptatrienyl]-1, 1-dimethyl-3-(4-sulfobutyl)-lH-benzo [e] dihydroindole inner salt, sodium salt. The content of C43H47N2NaO6S2 shall be between 94.0% and 105.0% based on the dry product.

Last Update：2024-01-02 23:10:35

IR-125 - Trait

Authoritative Data Verified Data
  • This product is dark green cyan or dark brown red powder; Odorless; Easy to deteriorate when exposed to light and heat.
  • This product is dissolved in water or methanol, and is almost insoluble in acetone.
Last Update：2022-01-01 11:57:27

IR-125 - Introduction

Slightly soluble in water.
Last Update：2022-10-16 17:24:52

IR-125 - Differential diagnosis

Authoritative Data Verified Data
  1. take about 10mg of this product, add 5ml of water to dissolve, add 10 drops of sodium hydroxide test solution, heat to about 60°C, add 10 drops of 3% hydrogen peroxide solution, that is, dark red and brown, place, the gradient is orange-yellow.
  2. the solution under the measurement of the content was taken and measured by ultraviolet-visible spectrophotometry (General rule 0401) to have the maximum absorption at the wavelengths of NM, NM and Nm.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 611).
  4. This product after burning ash, the identification of sodium salt and sulfate reaction (General rules 0301).
Last Update：2022-01-01 11:57:27

IR-125 - Exam

Authoritative Data Verified Data

sodium iodide

take about 0.2g of this product, weigh it accurately, add 0701 ml of water to dissolve it, add 1ml of nitric acid, shake it well, and measure it according to the potentiometric titration method (general rule), with silver nitrate titration solution (0.Olmol/L) titration. Each 1ml of silver nitrate titration solution (0.Olmol/L) is equivalent to 5.0% mg of NaL according to the dry product calculation, containing sodium iodide shall not exceed.

Related substances

take about 50mg of this product, put it in a 100ml measuring flask, add an appropriate amount of mobile phase, shake to dissolve, dilute to the scale with mobile phase, shake well, and use it as a test solution; take 1 ml accurately, put it in a 100ml measuring flask, dilute it to the scale with mobile phase, shake it well, and use it as a control solution. According to the high performance liquid chromatography (General 0512) test, using eighteen alkyl silane bonded silica gel as filler, phosphate buffer (pH 5.8)-acetonitrile-methanol (50:47:3) as mobile phase, the detection wavelength was 263nm. The number of theoretical plates shall not be less than 1000 calculated by the peak of indocyanine green, and the separation degree between the peak of indocyanine green and the adjacent impurity peaks shall meet the requirements. 10ul of the control solution was injected into the liquid chromatograph, and 10ul of the test solution and the control solution were respectively injected into the liquid chromatograph. The chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 3 times (3.0%) of the main peak area of the control solution.

loss on drying

take this product and dry under reduced pressure at 50°C for 3 hours, and the weight loss shall not exceed 6.0% (General rule 0831).

Heavy metals

take this product l. Put it in the crucible, heat it with small fire to carbonize, cool it, add 2ml of nitric acid and 5 drops of sulfuric acid, heat it until the white smoke is removed, and burn it at 500~600°C, make it into ash completely, let it cool down, add 2ml of hydrochloric acid, dry it on a water bath, wet the residue with 3 drops of hydrochloric acid, heat 7ml of water for 2 minutes, add 1 drop of phenolphthalein indicator solution, adjust to slightly red color with ammonia solution, add 0.4ml of dilute acetic acid, transfer to Nessler's colorimetric tube, filter if necessary, wash the Crucible with 2ml of water, and dilute to 10ml of water, as a test solution; another 2ml of nitric acid, 5 drops of sulfuric acid and 2ml of hydrochloric acid were taken, evaporated to dryness, 3 drops of hydrochloric acid were added to wet, 7ml of water was heated for 2 minutes, and 1 drop of phenolphthalein indicator solution was added, adjust to slightly red color with ammonia test solution, add 0.4ml of dilute acetic acid, transfer to another Nessler Cuvette, add 1.0ml of standard lead solution, and dilute to 10ml with water as control solution; add sodium sulfide glycerin solution (take 5g of sodium sulfide, add 10ml of water to dissolve, add 30ml of glycerin to mix, and keep it in the refrigerator for 3 months) 1 drop, shake, place for 5 minutes, check according to law (General 0821), containing heavy metals not more than 10 parts per million.

arsenic salt

take 0.25g of this product, add 0.5g of sodium hydroxide, mix, add a small amount of water, stir evenly, after drying, burn with small fire to make charring, then it should be heated at 600~700°C to make it ash completely, and then cooled. Add 5ml of hydrochloric acid and 23ml of water to dissolve the solution, and check according to law (General rule 0822), and it should comply with the regulation (0.0008%).

Last Update：2022-01-01 11:57:28

IR-125 - Content determination

Authoritative Data Verified Data

take an appropriate amount of this product, accurately weigh, add an appropriate amount of methanol to dissolve and quantitatively dilute to prepare a solution containing about 2ug per lml, according to UV-Vis spectrophotometry (General 0401), the absorbance was measured at a wavelength of 784mn and calculated as the absorption coefficient of C43H47N2Na06S2 was 3120.

Last Update：2022-01-01 11:57:29

IR-125 - Category

Authoritative Data Verified Data

diagnostic medication.

Last Update：2022-01-01 11:57:29

IR-125 - Storage

Authoritative Data Verified Data

shade, seal, and store in a cool and dry place.

Last Update：2022-01-01 11:57:29

IR-125 - Indocyanine green for injection

Authoritative Data Verified Data

This product is a sterile freeze-dried product of indocyanine green, containing indocyanine green (C43H47N2Na06S2) should be 90.0% to 110.0% of the label.

trait

This product is a dark green cyan loose solid; Easy to deteriorate when exposed to light and heat.

identification

  1. take about 10 mg of this product, add 5ml of water to dissolve, add 10 drops of sodium hydroxide test solution, heat to about 60°C, and add 10 drops of 3% hydrogen peroxide solution, that is, dark red and brown, place it, the gradient is orange-yellow.
  2. This product after burning ash, the identification of sodium salt and sulfate reaction (General rules 0301).

examination

  • acidity: take 50mg of this product, Add 10ml of water to dissolve it, and measure it according to law (General rule 0631). The pH value should be 5.0~7.0.
  • Related substances a solution containing about 0.5mg of indocyanine green per 1 ml was prepared by dissolving and diluting the product with a mobile phase, which was used as a test solution. The product was measured according to the method under the item of related substances of indocyanine green. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 5 times (5.0%) of the main peak area of the control solution.
  • the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 6.0%, first method 1).
  • bacterial endotoxin take this product, according to the law inspection (General 1143), each lmg cyanine green containing endotoxin amount should be less than 6.0EU.
  • sterile take this product, after dissolving with appropriate solvent, the membrane filtration method, according to the law inspection (General 1101), should comply with the provisions.
  • others should comply with the relevant provisions under injection (General 0102).

Content determination

take 5 pieces of this product, add an appropriate amount of methanol to dissolve indocyanine green respectively, put them in 10ml measuring flask, wash the container with methanol, merge the washing solution into the measuring flask, dilute with methanol to the scale, shake well, take appropriate amount with precision, and dilute quantitatively with methanol to make a solution containing about 2.5ug of indocyanine green per 1 ml, according to UV-Vis spectrophotometry (General rule 0401), the absorbance was measured at a wavelength of 784nm, and the content of each branch was calculated based on the absorption coefficient of C43H47N2Na06S2 being 3120, and the average content of 5 branches was obtained.

category

Same as indocyanine green.

specification

(l)10mg (2)25mg

storage

light shielding, closed, stored in cold place.

Last Update：2022-01-01 11:57:30

IR-125 - Reference Information

EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Clinical diagnosis of cardiovascular diseases Indocyanine green is commonly known as indigo green, diagnostic green needle, indocyanine green, is currently used in my country A contrast agent commonly used in the clinical diagnosis of cardiovascular diseases, indocyanine green angiography (ICG for short) is a fundus angiography similar to fluorescein fundus angiography, and the contrast agent is indocyanine green. Used to image choroidal and retinal vessels. Compared with fluorescence angiography, ICG has better resolution for choroidal vessels and poorer resolution for retinal vessels.
choroidal blood vessels are rich and blood volume is large, accounting for about 65% of the total amount of eyeball blood. The blood is supplied by the short posterior ciliary artery, and the vortex vein is returned. The inner capillary permeability is high, which supplies nutrients to the outer layer of the retina. The permeability of choroidal capillaries makes small molecular fluorescein easy to leak, while large molecular indocyanine green contrast agent is not easy to leak. It can show choroidal angiography clinically and can be used to observe choroidal diseases. Such as age-related macular degeneration, especially those with subretinal neovascularization, can not be seen clearly with fluorescence angiography, while indocyanine green angiography can find hidden neovascularization. It can also be used to examine choroidal tumors, central serous chorioretinopathy, various choroidal inflammation, degenerative diseases, vascular stripes and vascular obstruction.
usage and dosage for the diagnosis of cardiovascular diseases and the examination of their functional status. It is used to diagnose various liver diseases and to understand the degree of liver damage and its reserve function.
intravenous injection:
① determination of retention rate or plasma disappearance rate in blood: dilute indocyanine green drug to 5 mg/mL and 0.5 mg/kg with sterilized water for injection, and inject it into elbow vein within 10 seconds.
② cardiac output of children was 2.5 mg/kg and that of infants was 1.25 mg/kg.
③ measurement of liver blood flow in children: 2 mg/kg, intravenous injection time is 5 minutes.
intravenous drip: measure liver blood flow, dissolve 25mg indocyanine green for injection in a small amount of sterilized water for injection, dilute to 2.5-5.0 mg/mL with NS, inject 3mg intravenously, and then drop intravenously at a speed of 0.27-0.49 mg/min for about 50 minutes until blood samples are collected.
precautions 1. a few patients may have nausea, vomiting, dry mouth, belching, chest tightness, headache, vasculitis, urticaria and other symptoms.
2. contraindications have a history of allergy to this drug, and those who are allergic to iodine. Skin allergy test should be done before examination.
3. Be careful with severe liver damage, allergic constitution, asthma patients, pregnant women and lactating women.
4. Anti-shock first-aid drugs and instruments should be prepared before medication.
biological activity Indocyanine green(Cardiogreen) is a cyanine dye used for medical diagnosis. It is used to detect cardiac output and liver function, hepatic blood flow, and ophthalmic vascular photography.
use liver function determination diagnostic medication, IR laser dye.
category toxic substances
toxicity classification highly toxic
acute toxicity intravenous-rat LD50: 87 mg/kg; Intravenous-mouse LD50: 60 mg/kg
flammability hazard characteristics thermal decomposition discharges toxic nitrogen oxides, sulfur oxides, sodium oxide smoke
storage and transportation characteristics warehouse low temperature ventilation and drying
fire extinguishing agent water, carbon dioxide, foam, dry powder
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 02:00:08
IR-125
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Shanghai Yuanye Bio-Technology Co., Ltd.
Featured ProductsSpot supply
Product Name: Indocyanine Green Visit Supplier Webpage Request for quotation
CAS: 3599-32-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Indocyanine Green Visit Supplier Webpage Request for quotation
CAS: 3599-32-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Indocyanine Green Request for quotation
CAS: 3599-32-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: UJOVIRIDIN Request for quotation
CAS: 3599-32-4
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
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IR-125
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