IsofagomineHydrochlroide

Name	Isofagomine
Synonyms	Isofagomine IsofagomineHydrochlroide SOFAGOMINE, HYDROCHLORIDE ISOFAGOMINE, HYDROCHLORIDE 5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)- (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl (3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE
CAS	169105-89-9

Molecular Formula	C6H13NO3
Molar Mass	147.17
Density	1.279±0.06 g/cm3(Predicted)
Boling Point	317.2±37.0 °C(Predicted)
Solubility	Soluble in water and ethanol.
Appearance	Yellow low melting point solid
pKa	14.19±0.60(Predicted)
Storage Condition	2-8°C(protect from light)
MDL	MFCD04039581
In vivo study	Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.

Biological activity	Afegostat is a pharmacological partner, high affinity and specific and reversible binding Acid β-glucosidase (GCase) in the endoplasmic reticulum (ER).
target	GCase
in vivo research	Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.

Last Update：2024-04-09 20:52:54

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