D-Isofagomine; Isofagomine MedChemExpress (MCE)

Product Name	Isofagomine
Synonyms	Isofagomine IsofagomineHydrochlroide SOFAGOMINE, HYDROCHLORIDE ISOFAGOMINE, HYDROCHLORIDE 5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)- Synonyms Isofagomine IsofagomineHydrochlroide SOFAGOMINE, HYDROCHLORIDE ISOFAGOMINE, HYDROCHLORIDE 5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)- (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl (3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE
CAS	169105-89-9
EINECS
Chemical Formula	C6H13NO3
Molecular Weight	147.17
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Afegostat Afegostat MedChemExpress (MCE) HY-14829 169105-89-9 D-Isofagomine Descriptions Afegostat Afegostat MedChemExpress (MCE) HY-14829 169105-89-9 D-Isofagomine Isofagomine 99.96% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity. Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. GCase[1] In Vivo Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. \| \| \| \| \| \| \| \| \| \| [1]. Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct 11(4):840-56. [Content Brief]
Last Update	2025-04-01 14:45:47

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