KI-16425
Ki16425
CAS: 355025-24-0
Molecular Formula: C23H23ClN2O5S
KI-16425 - Names and Identifiers
KI-16425 - Physico-chemical Properties
| Molecular Formula | C23H23ClN2O5S |
| Molar Mass | 474.96 |
| Density | 1.353 |
| Melting Point | 59.5-60.5°C |
| Boling Point | 623.7±55.0 °C(Predicted) |
| Solubility | DMSO: 16mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 4.32±0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | Kil6425 preferentially inhibits LPA1 and LPA3 regulated responses, but has only moderate effect on lpa2. Ki16425 inhibited LPA-induced Ca2 responses in THP-1 cells, 3T3 fibroblasts, and A431 cells, but had only minor effects on PC-12 and HL-60 cells, this indicates that Ki16425 can be used to evaluate specific LPA receptors that have a short-term effect on LPA. Ki16425 acts on Swiss 3T3 fibroblasts to inhibit long-term DNA synthesis and LPA-induced cell migration. Ki1642 reduces LPA-induced activation of p42/p44 MAPK, which can be used as a weak activator of p42/p44 MAPK. The effect of Ki16425 on PC-12 cells also significantly decreased the activation of p42/p44 MAPK induced by NGF, and inhibited NGF-induced neural proliferation. Ki16425 significantly inhibited the expression of COX-2 protein induced by synovial fluid. Ki16425 also inhibited COX-2 expression by IL-1 of the enhancement of LPA. Kil6425 preferentially inhibits LPA1 and LPA3-regulated responses, but only has a moderate effect on lpa2. Ki16425 acts on THP-1 cells, 3T3 fibroblasts, and A431 cells, inhibiting LPA-induced Ca Ki1642 reduces LPA-induced activation of p42/p44 MAPK, and can act as a weak activator of p42/p44 MAPK. The effect of Ki16425 on PC-12 cells also significantly decreased the activation of p42/p44 MAPK induced by NGF, and inhibited NGF-induced neural proliferation. Ki16425 significantly inhibited the expression of COX-2 protein induced by synovial fluid. Ki16425 also inhibited COX-2 expression by IL-1 of the enhancement of LPA. |
| In vivo study | Ki16425 (30 mg/kg, I. P.) completely inhibited LPA-induced neuropathic behavior, pre-treatment with lysophosphatidic acid for 30 minutes, but not 90 minutes, indicating that Ki16425 is a transient inhibitor. Ki16425 acts on the dorsal root ganglion and also inhibits the upregulation of caα2t-1 induced by nerve injury, and acts on the spinal dorsal horn to inhibit the decrease of SP immune response. Ki16425 (30 mg/kg, I. P.) completely inhibited LPA-induced neuropathic behavior, pre-treated with lysophosphatidic acid for 30 minutes, but not 90 minutes, indicating that Ki16425 is a transient inhibitor. Ki16425 acts on the dorsal root ganglion and also inhibits the upregulation of caα2t-1 induced by nerve injury, and acts on the spinal dorsal horn to inhibit the decrease of SP immune response. |
KI-16425 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29349990 |
KI-16425 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.105 ml | 10.527 ml | 21.054 ml |
| 5 mM | 0.421 ml | 2.105 ml | 4.211 ml |
| 10 mM | 0.211 ml | 1.053 ml | 2.105 ml |
| 5 mM | 0.042 ml | 0.211 ml | 0.421 ml |
Last Update：2024-01-02 23:10:35
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CAS: 355025-24-0
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CAS: 355025-24-0
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Product Name: Ki16425 Visit Supplier Webpage Request for quotation
CAS: 355025-24-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 355025-24-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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