KPT-9274
KPT-9274
CAS: 1643913-93-2
Molecular Formula: C35H29F3N4O3
KPT-9274 - Names and Identifiers
KPT-9274 - Physico-chemical Properties
| Molecular Formula | C35H29F3N4O3 |
| Molar Mass | 610.62 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Boling Point | 857.5±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 32 mg/mL |
| pKa | 12.96±0.46(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In several human gastric cancer cell lines, KPT-9274 interferes with the PAK4 and NAD biosynthetic pathways, resulting in reduced G2/M transition, induction of apoptosis, and reduced cell invasion and migration. KPT-9274 inhibition of the PAK4 pathway reduces the nuclear localization of β-catenin and the Wnt/β-catenin signaling targets cyclin D1 and c-Myc. |
| In vivo study | KPT-9274 administration to an animal model of transplanted tumor with 786-O (VHL-mut) human gastric cancer cells caused a concentration-dependent inhibition of tumor growth without significant toxicity. KPT-9274 also has significant anti-tumor activity in xenograft models transplanted with pancreatic ductal adenocarcinoma and cancer stem cells by subcutaneous injection. KPT-9274 has a favorable pharmacokinetic profile in vivo and is well tolerated in mice, with no toxic effects observed at doses of 200 mg/kg of the drug intravenously or orally. |
KPT-9274 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.638 ml | 8.188 ml | 16.377 ml |
| 5 mM | 0.328 ml | 1.638 ml | 3.275 ml |
| 10 mM | 0.164 ml | 0.819 ml | 1.638 ml |
| 5 mM | 0.033 ml | 0.164 ml | 0.328 ml |
Last Update：2024-01-02 23:10:35
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Product Name: KPT-9274 Visit Supplier Webpage Request for quotationCAS: 1643913-93-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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