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L-Histidine

L-Histidine

CAS: 71-00-1

Molecular Formula: C6H9N3O2

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L-Histidine - Names and Identifiers

Name L-Histidine
Synonyms His
H-His-OH
Histidine
L-Histidine
L-[+]-Histidine
L-Histidine Base
L-HISTIDINE BASE
L-Histidine,free base
(s)-1h-imidazole-4-alanin
3-(1h-imidazol-4-yl)-l-alanin
(s)-1h-imidazole-4-propanoicaci
4-(2-Amino-2-carboxyethyl)imidazole
(s)-4-(2-amino-2-carboxyethyl)imidazole
(s)-alpha-amino-1h-imidazole-4-propanoicacid
1H-Imidazole-4-propanoic acid, alpha-amino-, (S)-
(S)-2-Amino-3-(4-imidazolyl)propionic acid~H-His-OH
CAS 71-00-1
EINECS 200-745-3
InChI InChI:1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)
InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N

L-Histidine - Physico-chemical Properties

Molecular FormulaC6H9N3O2
Molar Mass155.15
Density1.3092 (rough estimate)
Melting Point282°C (dec.)(lit.)
Boling Point278.95°C (rough estimate)
Specific Rotation(α)12.4 º (c=11,6N HCl)
JECFA Number1431
Water Solubility41.6 g/L (25 ºC)
Solubility Soluble in water (4.3g/100ml,25°C), extremely insoluble in ethanol, insoluble in ether.
AppearanceWhite crystal or crystalline powder
ColorWhite to off-white or pale yellow
Maximum wavelength(λmax)['λ: 260 nm Amax: 0.05',
, 'λ: 280 nm Amax: 0.05']
Merck14,4720
BRN4673585
pKa1.8(at 25℃)
PH7.0-8.0 (25℃, 0.1M in H2O)
Storage Condition2-8°C
StabilityStable. Incompatible with strong oxidizing agents.
SensitiveSensitive to light
Refractive Index13 ° (C=11, 6mol/L H
MDLMFCD00064315
Physical and Chemical PropertiesMelting Point 282°C
specific rotation 12.4 ° (c = 11,6N HCl)
water-soluble 41.6g/L (25°C)
UseUsed as pharmaceutical raw materials and food additives

L-Histidine - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS24/25 - Avoid contact with skin and eyes.
S36/37 - Wear suitable protective clothing and gloves.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S22 - Do not breathe dust.
WGK Germany2
RTECSMS3070000
FLUKA BRAND F CODES10-23
TSCAYes
HS Code29332990
ToxicityLD50 orally in Rabbit: > 5110 mg/kg

L-Histidine - Nature

Open Data Verified Data
  • This product is colorless needle-like or plate-like crystal. Odorless, slightly bitter. 227 degrees Celsius softening, 277 degrees Celsius decomposition. Soluble in water (7. 59%,25 ℃), extremely difficult to dissolve in alcohol, insoluble in ether. Its imidazole group is easy to form a complex salt with metal ions, and its hydrochloride is commonly used. In vivo by 5 Phosphoribosyl pyrophosphate (PRPP) and ATP ATP synthesis. It is a synthetic precursor of histamine, urinal acid, Carnosine and other biological substances.
  • It is a semi-essential amino acid, but it is essential for the growth and development of infants and young children. In patients with uremia, the supply of histidine is conducive to the full use of amino acids in patients. Long-term lack of histidine will appear negative nitrogen balance, skin damage, serum albumin decreased, especially hematocrit decreased. It is involved in the synthesis of hemoglobin in the role of blood.
Last Update：2024-01-02 23:10:35

L-Histidine - Preparation Method

Open Data Verified Data
  1. hydrolysis the pig blood powder was hydrolyzed with hydrochloric acid at 110-115 ° C. For 24h, and the peptide chain of the pig blood powder globule protein was cleaved to generate free amino acids. The hydrolysate is filtered, diluted, and passed through a cation exchange column, and the various amino acid components are exchanged on the resin in a certain order. Then, under the action of the eluent, the amino acid is transferred from the resin phase to the solution phase, and L-histidine is concentrated and crystallized to obtain L-histidine. L-histidine can also be extracted from hydrolysates of defatted soybeans.
  2. direct fermentation method.
Last Update：2022-01-01 11:10:19

L-Histidine - Use

Open Data Verified Data
  • amino acid drugs. The main components of amino acid infusion and comprehensive amino acid preparation. Usage and dosage for the treatment of gastric ulcer, anemia, allergy, etc. 5ml of 4% solution was injected subcutaneously or intramuscularly.
  • the food additive is used as a flavor enhancer and a nutritional supplement, and can be added to improve the flavor in the manufacture of bread, and is applied to infant food and post-operative patient food.
Last Update：2022-01-01 11:10:20

L-Histidine - Safety

Open Data Verified Data
  • low toxicity, adult toxic dose> 64g/d, adult daily intake of 32G can be tolerated for a short period of time; Mice, rats, oral LD50>15g/kg, subcutaneous LD50 >lOg/kg, rats intraperitoneal injection of LD50>8 g/kg; Mice, rats, intravenous injection of LD50>2g/kg.
  • light-shielding, closed and dry storage.
Last Update：2022-01-01 11:10:20

L-Histidine - Reference Information

FEMA3694 | L-HISTIDINE
pH range of acid-base indicator discoloration 7 - 8 at 15.5g/l at 25°C
NIST chemical information information provided by: webbook.nist.gov (external link)
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
Introduction the product form of L-histidine is white powder crystal. It is an important amino acid raw material, is a kind of human semi-essential amino acids, mainly used as amino acid infusion and oral amino acid preparation of raw materials; In addition, it is also the treatment of heart disease, anemia, rheumatoid arthritis, the important drugs such as peptic ulcer and solid hepatitis are widely used in the field of medicine.
trait L-histidine is colorless needle-like or plate-like crystal, softened at 277 °c and decomposed at 287 °c. 25 ° C in water solubility of 41.9g/L, very slightly soluble in alcohol, insoluble in ether and chloroform. Sweet.
uses uses of L-histidine: nutritional supplements, sweeteners. Purposes: used as a nutrition enhancer, is an amino acid infusion, an important component of compound amino acid preparations. Can be used to treat gastric ulcer. Also used in biochemical research.
nutritional supplements. Essential components of amino acid infusion and comprehensive amino acid preparation. Medicine for the treatment of gastric ulcer, anemia, allergies, etc.
It is used in biochemical research, and is used in medicine to treat gastric ulcer, anemia, allergy, etc.
amino acid drugs. The main components of amino acid infusion and comprehensive amino acid preparation are used to treat gastric ulcer, anemia, angina pectoris, aortitis, cardiac insufficiency and other cardiovascular diseases. Adverse reactions and contraindications: low toxicity, adult toxic dose> 64g/day. Such as histamine hydrochloride injection of headache, flushing, heat.
as a Nutrition Fortifier, it is an important component of amino acid infusion and compound amino acid preparation. Can be used to treat gastric ulcer. Also used in biochemical research.
used as pharmaceutical raw materials and food additives
range of use addition amount of L-histidine: according to national standards, the recommended dosage is 1‰ to 3.
content analysis accurately weigh the sample pre-dried at 105 ℃ for 3H, after dissolving in 3ml formic acid and 50ml glacial acetic acid, titrate with 0.1mol/L perchloric acid and determine the end point by potentiometry. At the same time, the blank test was carried out and the necessary correction was made. Perchloric acid corresponds to 15.52mg of L-histidine (C6H9N3O2) per mL of 0.1mol/L.
toxicity can be used safely in foods (FDA § 172.320,2000).
usage limit accounts for 2.4% of the total protein in food (FDA § 172.320,2000). FEMA: baked goods, meat products, dairy products, candy, frosting, all 150mg/kg.
production method extracted from pig blood and bovine blood. Blood Powder was prepared by spray drying of pig blood, about 18kg of blood powder per 100kg of pig blood. L-histidine is commonly used as its hydrochloride ([7048-02-4]). Concentrate the eluate containing L-histidine until crystallization occurs, adjust to pH 2.5 with hydrochloric acid while hot, immediately add ethanol twice the amount of the solution, stand, precipitate, filter, the crude L-histidine hydrochloride is obtained, which is decolorized, recrystallized and dried to obtain the finished product. L-histidine can also be extracted from hydrolysates of defatted soybeans.
There are two main methods. One is a direct fermentation method, using glucose as a carbon source, and inducing drug-resistant strains of Corynebacterium Flavobacterium Corynebacterium glutamicum and the like by a direct fermentation method. The second is protein hydrolysis. The hydrolysis method is described in detail below. With Pig (cattle) blood meal or pig hair or hoof a as raw material, acid hydrolysis, and then separated and refined. Hydrolysis 50kg of pig blood powder and 4 times the amount of 6mol/L HCl were put into a hydrolysis tank, heated and maintained at 110-120 ° C., and subjected to hydrolysis for 24 hours. Preparation of upper column diluent the hydrolysate of the previous step was concentrated under reduced pressure, distilled water was added, and the acid was distilled off repeatedly for 3-4 times until the distillate was discharged without hydrochloric acid. Dilute the concentrated solution with distilled water to 500L, adjust the pH to 3.5-4 with concentrated ammonia water, add 20% of activated carbon to the Blood Powder, heat at 90 ℃, keep warm, stir, decolorize and filter for 6h while hot, the filtrate was allowed to stand overnight to precipitate, filtered, diluted to 2.5% with distilled water (based on the amount of blood powder), and adjusted to pH 2.5 with concentrated HCl to obtain the column diluent. Upper column separation, water washing, elution the above dilution on the column. 732 ×, PVC material, with 001 × 7 () strong acid styrene type cation exchange resin, 1730mm High, flow rate 1L/min, until L histidine appears in effluent, the upper column was stopped. Wash with water 500L, flow rate 1.5L/min. Collect the pH 7.0-10.0 fractions. After the collection is finished, recoil the resin with water for 15min, and then use 2 times the amount of HCl 1.5-2mol/L along the flow dynamic regeneration, the flow rate is 5-13L/min, it was then washed with water until pH 4. The eluent of histamine acid was refined, removed ammonia under reduced pressure, concentrated to dryness, then dissolved in 40L distilled water, adjusted to pH 3-3.2 with 6mol/L HCl, and 1kg activated carbon was added, heated at 90 ℃, stirred, decolorized for 30min, filter the residue while hot to take the filtrate, concentrate in a thin film evaporator, stand for 48h to precipitate crystals, filter to take crystals, wash with 95% ethanol, vacuum dry at 80 ℃ for 4H, L-histamine acid hydrochloride.
The crude L-histamine acid monohydrochloride was obtained by refluxing dry flour and hydrochloric acid as raw materials for several hours, filtering and washing, and then treating with activated carbon to obtain a pure product after recrystallization and purification.
From the basic amino acid fraction of the protein hydrolysate, it was obtained by separation with an ion exchange resin.
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 20:13:35
L-Histidine
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Shanghai Yuanye Bio-Technology Co., Ltd.
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Henan Julong Biological Engineering Co.,Ltd
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CAS: 71-00-1
Tel: +86 375 6971958
Email: diana@julongshengwu.com
Mobile: +8613938854848
QQ: 1176983917 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Product Name: Histidine Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: L-Histidine Request for quotation
CAS: 71-00-1
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: L-Histidine Request for quotation
CAS: 71-00-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Guangzhou Yuanda New Material Co.,Ltd
Product Name: L-Histidine Request for quotation
CAS: 71-00-1
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: L-Histidine Request for quotation
CAS: 71-00-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Wuhan Xingzhongcheng Chemical limited company
Spot supply
Product Name: L-Histidine Request for quotation
CAS: 71-00-1
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217 Click to send a QQ message
Wechat: 18627766980
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: L-Hisidine Visit Supplier Webpage Request for quotation
CAS: 71-00-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Henan Julong Biological Engineering Co.,Ltd
Product Name: L-histidine Request for quotation
CAS: 71-00-1
Tel: +86 375 6971958
Email: diana@julongshengwu.com
Mobile: +8613938854848
QQ: 1176983917 Click to send a QQ messageSend QQ message
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L-Histidine
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