M-CHLOROPROPIOPHENONE
3'-Chloropropiophenone
CAS: 34841-35-5
Molecular Formula: C9H9ClO
M-CHLOROPROPIOPHENONE - Names and Identifiers
| Name | 3'-Chloropropiophenone |
| Synonyms | MCPP M-CHLOROPROPIOPHENONE m-chlorophenylacetone 3'-Chloropropiophenone beta-Chloropropiophenone 3-CHLORO-1-PHENYL-PROPANONE 2-Chloroethyl phenyl ketone 3-CHLOROPHENYL ETHYL KETONE (3-CHLOROPHENYL)PROPAN-1-ONE 3-chloro-1-phenylpropan-1-one 3-Chloro-1-phenyl-1-propanone 1-(3-CHLOROPHENYL)-1-PROPANONE 1-(3-Chlorophenyl)-1-propanone 1-(3-chlorophenyl)propan-1-one 1-(4-chlorophenyl)propan-1-one 3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE 3-Chloro-Propiophenone(M-ChloroProiophenone) |
| CAS | 34841-35-5 |
| EINECS | 252-242-3 |
| InChI | InChI=1/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3 |
| InChIKey | PQWGFUFROKIJBO-UHFFFAOYSA-N |
M-CHLOROPROPIOPHENONE - Physico-chemical Properties
| Molecular Formula | C9H9ClO |
| Molar Mass | 168.62 |
| Density | 1.1115 (rough estimate) |
| Melting Point | 45-47°C(lit.) |
| Boling Point | 124°C14mm Hg(lit.) |
| Flash Point | >230°F |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0.0266mmHg at 25°C |
| Appearance | Bright yellow crystal |
| Color | White to light yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5350 (estimate) |
| MDL | MFCD00009925 |
| Physical and Chemical Properties | Melting point 43-47°C boiling point 124°C (14 torr) |
| Use | For the synthesis of the drug bupropion |
M-CHLOROPROPIOPHENONE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29147000 |
M-CHLOROPROPIOPHENONE - Reference Information
| LogP | 3.041 |
| introduction | 3-chlorophenylacetone is a key intermediate for the synthesis of bupropion hydrochloride, dapoxetine and maravero. Ampropion hydrochloride is an antidepressant. It is a blocker for the absorption of serotonin and norepinephrine by weak neurons. It is suitable for patients with unknown efficacy of other depressive drugs or who cannot tolerate depression. At the same time, bupropion hydrochloride can also be used for the adjuvant treatment of smoking cessation, viral infection or sexual dysfunction. |
| application | 3 '-chlorophenylacetone is a key intermediate for the synthesis of bupropion hydrochloride, dpaoxetine and malavero. It can be mainly used in laboratory organic synthesis and chemical production. |
| preparation | 3 '-chlorophenylacetone is obtained by chlorination of phenylpropanone. the chemicals used in this method are: phenylpropanone, trichloride metal salt, solvent a, chlorine Cl2, where solvent a can dissolve both phenylpropanone and miscible trichloride, and its reaction equation is as follows: its operation steps are as follows: the first step is to add a proper amount of metal trichloride salt and solvent A to the reaction kettle, drop the phenylketone solution in the stirred state, introduce chlorine Cl2, perform chromatographic tracking of the reaction in the temperature range of 15~70 ℃, and stop the chlorination for about 6~10 hours; the second step, low temperature hydrolysis; the third step, water washing and stratification; the fourth step, decompression distillation to obtain the target crude product; the fifth step is to rectify the crude product at a temperature of about 170 ℃ to obtain a fine product with a content of 99.7% ~ 99.9%; the yield is 88% ~ 90%; |
| Uses | Used in the synthesis of the drug bupropion Organic synthesis and pharmaceutical synthesis intermediates can be used in the synthesis of bupropion. |
Last Update：2024-04-09 02:00:08
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View History
M-CHLOROPROPIOPHENONE
(S)-N-Boc-3-四氢吡咯乙酸
SULPHUR TRIOXIDE
4-[(3-Methyl-2-butenyl)oxy]piperidinehydrochloride
BETA-N-INDOLE PROPIONIC ACID
(S)-N-Boc-3-四氢吡咯乙酸
SULPHUR TRIOXIDE
4-[(3-Methyl-2-butenyl)oxy]piperidinehydrochloride
BETA-N-INDOLE PROPIONIC ACID