MIT
2-Methyl-4-Isothiazoline-3-one
CAS: 2682-20-4
Molecular Formula: C4H5NOS
MIT - Names and Identifiers
MIT - Physico-chemical Properties
| Molecular Formula | C4H5NOS |
| Molar Mass | 115.15 |
| Density | 1.25 (14% aq.) |
| Melting Point | 254-256°C(lit.) |
| Boling Point | bp0.03 93° |
| Water Solubility | 489g/L at 20℃ |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | <0.1 mm Hg ( 25 °C) |
| Appearance | neat |
| Color | Yellow Low melting |
| BRN | 606203 |
| pKa | -2.03±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| MDL | MFCD01742315 |
| Physical and Chemical Properties | white or off-white crystalline powder |
| Use | Is a broad range of bactericidal preservatives, can effectively kill algae, bacteria and fungi. The active single agent can be widely used in industrial cooling water, oil field back tank water, paper industry, pipeline, paint, paint, rubber and cosmetics, photographic film and washing products and other industries. The effective dosage is small, non-toxic and pollution-free, and it is easy to mix in various formulations, and the PH is widely used. After dilution and use concentration, it is easy to be biodegradable into non-toxic and pollution-free substances. Low toxicity, no residual emissions, and a variety of emulsifiers, surfactants and protein ingredients with good compatibility. MIT can effectively kill a variety of bacteria at low concentrations, especially suitable for the preservation of cosmetics and personal care products. Applicable pH range pH2.0-12.0, miscible with water, can be added in any process, easy to operate |
MIT - Risk and Safety
| Risk Codes | R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R50 - Very Toxic to aquatic organisms R43 - May cause sensitization by skin contact R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R37 - Irritating to the respiratory system R23 - Toxic by inhalation R22 - Harmful if swallowed |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24 - Avoid contact with skin. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | FE1250000 |
| HS Code | 29349990 |
| Hazard Class | 8 |
| Packing Group | III |
MIT - Introduction
2-Methyl-4-isothiazolin-3-one is a potent biocide useful for controlling microbial growth.
Last Update：2022-10-16 17:24:09
MIT - Reference Information
| LogP | -0.486 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | methyl isothiazolinone (methylisothiazolinone,MIT) is a new fungicide imported from Europe in China. Isothiazolinones can inhibit the growth and reproduction of various microorganisms (such as bacteria, fungi, yeasts, etc.), and are a kind of broad-spectrum fungicides that are widely used. Compared with other types of fungicides, isothiazolinone fungicides have the advantages of obvious effect and fast action for controlling the growth and metabolism of microorganisms and preventing the formation of biofilms. |
| mechanism of action | isothiazolinone is a water treatment agent with excellent performance, good miscibility, and can be mixed with various corrosion inhibitors such as chlorine, scale inhibitor and dispersant, Most anion, cationic and non-ionic surfactants are miscible, commodities circulating on the market are usually composed of 5-chloro-2-methyl-4-isothiazolin-3-one (CMI) and 2-methyl-4-isothiazolin-3-one (MI) At the same time, metal nitrite or metal nitrate will be added to improve stability and prevent decomposition, the mechanism of action of isothiazolinone is to kill by breaking the bonds between bacteria and algae proteins. After contact with microorganisms, it can quickly and irreversibly inhibit its growth, resulting in the death of microbial cells. Bacteria (sulfate reducing bacteria, mud forming bacteria), fungi (iron oxidizing bacteria, mold, yeast), algae, etc. have strong inhibitory and killing effects. It has the characteristics of high killing efficiency, good degradability, no residue, safe operation, good compatibility, strong stability, low use cost, etc. At high doses, it has a significant effect on biological slime peeling. It has been widely used in steel smelting, oilfield water injection, thermal power generation, papermaking, oil refining, chemical industry, textile, industrial cleaning, pesticides, cutting oil water-based coatings, daily chemicals, Ink, dyes, leather and other fields. |
| synthesis method | 230 grams of mixed chloride (chlorine ratio 3:l) is dispersed into ethyl acetate to obtain 1000 grams of solution, neutralized with ammonia and filtered. The organic layer of ethyl acetate is distilled to obtain CMI, which is prepared with ethylene glycol to form a 10% solution; the water layer is an aqueous solution of methyl isothiazolinone. Referring to similar documents, our experiment gives the following results: l chocolate mixed chlorinated material is added to 150g of 5% magnesium chloride solution, heated to 30 ℃ for dissolution, a certain amount of organic solvent is added, stirred for 30 minutes, and left to layer. Take the upper water solution, add a small amount of organic solvent, fully stir and extract to obtain 180 grams of aqueous solution, adjust the PH to 55 with magnesium oxide, and obtain colorless and transparent methyl isothiazolinone aqueous solution. |
| use | generally used as preservative in bath, shampoo and washing liquid, industrially used in cooling water, circulating water, papermaking and paint coatings is an efficient antimicrobial drug with broad-spectrum bacteriostatic ability, used for sterilization and anticorrosion of papermaking coatings, oil field water injection, daily chemical industry, etc. is a widely used sterilization preservative, can effectively kill algae, bacteria and fungi. The active single agent can be widely used in industrial cooling water, oil field return tank water, paper industry, pipeline, coating, paint, rubber, cosmetics, photosensitive film and washing products and other industries. The effective dosage is small, non-toxic and non-polluting, and it is easy to mix in various formulas. The PH has a wide range of applications. After diluting the concentration, it is easy to be biodegraded into non-toxic and non-polluting substances. Low toxicity, no residue, good compatibility with various emulsifiers, surfactants and protein components. MIT can effectively kill a variety of bacteria at low concentrations, especially suitable for the preservation of cosmetics and personal care preparations. The applicable pH range is pH2.0-12.0, miscible with water, can be added in any process, and is easy to operate |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
Supplier List
Featured ProductsSpot supply
Product Name: Methylisothiazolinone；2-Methyl-4-Isothiazolin-3-one Request for quotationCAS: 2682-20-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Featured ProductsSpot supply
Product Name: 2-Methyl-4-isothiazolin-3-one(MIT) Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotation
CAS: 2682-20-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 2682-20-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-17505207175
Email: r@reformchem.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Methylisothiazolinone Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 2-Methyl-4-isothiazolin-3-one Visit Supplier Webpage Request for quotation
CAS: 2682-20-4
Tel: 0510-83593312
Email: sales@honorshinechem.com
Mobile: 13665125081
QQ: 2404125167
Send QQ message
Descriptions:
It is used for bactericidal and bacteriostatic
in water system such as cosmetics, coatings, polymer synthetic emulsion, etc.
Product List: View Catalog
CAS: 2682-20-4
Tel: 0510-83593312
Email: sales@honorshinechem.com
Mobile: 13665125081
QQ: 2404125167
Descriptions:
It is used for bactericidal and bacteriostatic
in water system such as cosmetics, coatings, polymer synthetic emulsion, etc.Product List: View Catalog
Spot supply
Product Name: Methylisothiazolinone Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Descriptions:
It is used for bactericidal and bacteriostatic
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotation
CAS: 2682-20-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Descriptions:
It is used for bactericidal and bacteriostatic
Product List: View Catalog
CAS: 2682-20-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Descriptions:
It is used for bactericidal and bacteriostatic
Product List: View Catalog
Featured ProductsSpot supply
Product Name: Methylisothiazolinone；2-Methyl-4-Isothiazolin-3-one Request for quotationCAS: 2682-20-4
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Featured ProductsSpot supply
Product Name: 2-Methyl-4-isothiazolin-3-one(MIT) Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotation
CAS: 2682-20-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 2682-20-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-17505207175
Email: r@reformchem.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Spot supply
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotationCAS: 2682-20-4
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Methylisothiazolinone Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 2-Methyl-4-isothiazolin-3-one Visit Supplier Webpage Request for quotation
CAS: 2682-20-4
Tel: 0510-83593312
Email: sales@honorshinechem.com
Mobile: 13665125081
QQ: 2404125167Send QQ message
Descriptions:
It is used for bactericidal and bacteriostatic
in water system such as cosmetics, coatings, polymer synthetic emulsion, etc.
Product List: View Catalog
CAS: 2682-20-4
Tel: 0510-83593312
Email: sales@honorshinechem.com
Mobile: 13665125081
QQ: 2404125167
Descriptions:
It is used for bactericidal and bacteriostatic
in water system such as cosmetics, coatings, polymer synthetic emulsion, etc.Product List: View Catalog
Spot supply
Product Name: Methylisothiazolinone Visit Supplier Webpage Request for quotationCAS: 2682-20-4
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Descriptions:
It is used for bactericidal and bacteriostatic
Product Name: 2-Methyl-4-Isothiazoline-3-one Request for quotation
CAS: 2682-20-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Descriptions:
It is used for bactericidal and bacteriostatic
Product List: View Catalog
CAS: 2682-20-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Descriptions:
It is used for bactericidal and bacteriostatic
Product List: View Catalog
View History
MIT
173838-67-0
异硫氰酸异丁酯
3-氨基-7-溴-4-异喹啉甲腈
氯二氟乙酸烯丙酯
TANTALUM HYDRIDE
TimTec1_004164
二异丙基偶氮羧酸盐
NAPHTHALENE-2-SULPHONAMIDE
Budenoside EP Impurity I
173838-67-0
异硫氰酸异丁酯
3-氨基-7-溴-4-异喹啉甲腈
氯二氟乙酸烯丙酯
TANTALUM HYDRIDE
TimTec1_004164
二异丙基偶氮羧酸盐
NAPHTHALENE-2-SULPHONAMIDE
Budenoside EP Impurity I