Methylisothiazolinone MedChemExpress (MCE)

Product Name	2-Methyl-4-Isothiazoline-3-one
Synonyms	MIT Skycide 100 Methylisothiazolinone Isothiazolone,2-methyl- 2-Methyl-3-isothiazolone Isothiazolone, 2-methyl- 2-Methylisothiazol-3-one Synonyms MIT Skycide 100 Methylisothiazolinone Isothiazolone,2-methyl- 2-Methyl-3-isothiazolone Isothiazolone, 2-methyl- 2-Methylisothiazol-3-one Methyl-3(2H)-isothiazolone 2-Methyl-Isothiazolin-3-one 2-methyl-3(2h)-isothiazolon 2-METHYL-3(2H)-ISOTHIAZOLONE 2-Methyl-4-Isothiazolin-3-One 2-METHYL-4-ISOTHIAZOLIN-3-ONE 2-METHYL-4-ISOTHIAZOLINE-3-ONE 2-Methyl-4-Isothiazoline-3-one 2-Methyl-4-Isothiazolin-3-Ketone N-METHYL-3-OXODIHYDRO ISOTHIAZOLE 2-Methyl-4-Isothiazoline-3-Ketone 2-Methyl-2,3-dihydroisothiazol-3-one 1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA
CAS	2682-20-4
EINECS	220-239-6
Chemical Formula	C4H5NOS
Molecular Weight	115.15
inchi	InChI=1/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3
Package	10 mM * 1 mL;100 mg;250 mg
Price	Email to quote
Descriptions	Methylisothiazolinone Methylisothiazolinone MedChemExpress (MCE) HY-W010520 2682-20-4 99.37% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Methylisothiazolinone Methylisothiazolinone MedChemExpress (MCE) HY-W010520 2682-20-4 99.37% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Methylothiazolinone is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels. Methylisothiazolinone (0-8 μg/mL, 24 h) induces cell apoptosis and inflammatory response by activating matrix metalloproteinases (MMPs) in human bronchial epithelial cells[1]. Methylisothiazolinone (0-2.5 μg/mL, 1 h) can cause mitochondrial damage in brain endothelial cells[2]. Methylisothiazolinone (0.15 mg/kg once i.v.) can increase the susceptibility of rat cerebral vascular endothelium to endogenous pathological stimuli and lead to mitochondrial damage[2]. Methylisothiazolinone (20 or 40 μL handling skin (20 μL), days 1 and 8 intranasal instillation (40 μL), day 15) can cause sensitization in asthmatic mice when handled on the skin[3]. Methylisothiazolinone (0.1875 mg/kg CMIT/MIT once daily 15 days epidermal contact) promotes the development of atopic dermatitis in mice through Th2/Th17 related immune response dysregulation[4]. \| \| \| \| \| \| \| \| \| \| [1]. Park EJ, et al. Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells. Toxicol In Vitro. 2020 Feb 62:104661. [Content Brief] [2]. Kim D, et al. Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium. Toxicol Lett. 2022 Aug 1 366:45-57. [Content Brief] [3]. Devos FC, et al. Methylisothiazolinone: dermal and respiratory immune responses in mice. Toxicol Lett. 2015 Jun 15 235(3):179-88. [Content Brief] [4]. Go HN, et al. Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model. Sci Rep. 2020 Mar 5 10(1):4099. [Content Brief]
Supplier Website	https://www.medchemexpress.com/methylisothiazolinone.html
Last Update	2025-05-21 16:50:25

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