N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide

Name	N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide
Synonyms	Mepicaine Polocaine Carbocain Carbocaine DL-Mepivacaine 1-Methyl-2',6'-pipecoloxylidide 2',6'-Pipecoloxylidide, 1-methyl- (6CI, 8CI) N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (9CI)
CAS	96-88-8
EINECS	202-543-0

Molecular Formula	C15H22N2O
Molar Mass	246.35
Density	0.9978 (rough estimate)
Melting Point	150-151°
Boling Point	389.35°C (rough estimate)
Water Solubility	2.217g/L(25 ºC)
pKa	14.85±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.6280 (estimate)
In vitro study	Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
biological activity	Mepivacaine is an amide-type agent that temporarily causes local loss of consciousness. Mepivacaine binds to specific voltage-gated sodium channels on neuronal cell membranes, inhibiting sodium influx and membrane depolarization.

Last Update：2024-04-10 22:29:15