N-BOC-trans-4-hydroxy-L-proline
boc-L-hydroxyproline
CAS: 13726-69-7;331442-12-7
Molecular Formula: C10H17NO5
N-BOC-trans-4-hydroxy-L-proline - Names and Identifiers
N-BOC-trans-4-hydroxy-L-proline - Physico-chemical Properties
| Molecular Formula | C10H17NO5 |
| Molar Mass | 231.25 |
| Density | 1.312±0.06 g/cm3(Predicted) |
| Melting Point | 123-127°C(lit.) |
| Boling Point | 390.9±42.0 °C(Predicted) |
| Specific Rotation(α) | -78 º (in H2O) |
| Flash Point | 190.2°C |
| Water Solubility | very faint turbidity |
| Vapor Presure | 9.99E-08mmHg at 25°C |
| Appearance | White solid |
| Color | White to off-white |
| BRN | 4295484 |
| pKa | 3.80±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | -68 ° (C=1, MeOH) |
| MDL | MFCD00053370 |
| Physical and Chemical Properties | White solid. |
N-BOC-trans-4-hydroxy-L-proline - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2933 99 80 |
| Hazard Class | IRRITANT |
N-BOC-trans-4-hydroxy-L-proline - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| background | proline is one of the important amino acids for the synthesis of human protein, an important raw material for amino acid infusion, and a major intermediate for the synthesis of captopril, enalapril and other first-line antihypertensive drugs. it has been widely used in food and medicine industries. It can be used for amino acid injections, compound amino acid infusions, food additives, nutritional supplements, etc.; it can be used for biochemical research, and it can be used for malnutrition, protein deficiency, gastrointestinal diseases, scalds and postoperative protein supplements in medicine, etc.; It can be used for nutritional supplements, flavors, amino-carbonyl reactions occur in co-heating with sugar, which can generate special fragrance substances, which can be used as spices according to my country's GB2760-86 regulations; it can be used for amino acid drugs. It is one of the raw materials for compound amino acid infusion. It is used for malnutrition, protein deficiency, severe gastrointestinal diseases, burns and protein supplementation after surgical operations; it can be used for pharmaceutical raw materials and food additives. |
| application | Boc-L-proline is mainly used in polypeptide synthesis, mainly used in a variety of drugs and biotechnology applications. |
| preparation | 1. add 18.1g L-proline and 10ml water to the reaction bottle and stir. Add 16g of 0.1mol/L lye of sodium hydroxide to alkaline. Add 8g of (Boc)2O for 1 hour, 8g of (Boc)2O for 1 hour, and finally 9g of (Boc)2O for 3 hours. 2. Use petroleum ether 1ml/time to extract impurities three times. After 3mol/L hydrochloric acid adjusts PH = 3, ethyl acetate 0.5L/time is used to extract the product three times. Combine ester layers and wash with brine to neutral. Add 15 grams of anhydrous sodium sulfate and dry for 6 hours. 3. Filter, concentrate and dry the filtrate under reduced pressure, add 50ml petroleum ether, stir and crystallize. Centrifuge out the product and dry it. The product 26.3g is obtained. The yield is 93.57%. |
Last Update：2024-04-09 19:05:10
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View History
N-BOC-trans-4-hydroxy-L-proline
1-ETHOXY-2-METHYLPROPANE
N-CYCLOHEXYL ASPARTIC ACID
1-Thia-3-silacyclohexane, 3,3,6-trimethyl-
high purity Polyethylene Glycol Monoallyl Ether
Folic acid EP Impurity C
牛血纤连蛋白
2,3-DIMETHYLIODOBENZENE
5-Fluoro-2-methylphenylhydrazineHCl
纳米氧化铽
1-ETHOXY-2-METHYLPROPANE
N-CYCLOHEXYL ASPARTIC ACID
1-Thia-3-silacyclohexane, 3,3,6-trimethyl-
high purity Polyethylene Glycol Monoallyl Ether
Folic acid EP Impurity C
牛血纤连蛋白
2,3-DIMETHYLIODOBENZENE
5-Fluoro-2-methylphenylhydrazineHCl
纳米氧化铽