N-EPSILON-T-BUTOXYCARBONYL-D-LYSINE - Names and Identifiers
N-EPSILON-T-BUTOXYCARBONYL-D-LYSINE - Physico-chemical Properties
Molecular Formula | C11H22N2O4
|
Molar Mass | 246.3 |
Density | 1.113±0.06 g/cm3(Predicted) |
Boling Point | 412.9±40.0 °C(Predicted) |
Flash Point | 203.5°C |
Vapor Presure | 5.65E-08mmHg at 25°C |
Appearance | Powder |
Color | White |
pKa | 2.53±0.24(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
Refractive Index | 1.485 |
N-EPSILON-T-BUTOXYCARBONYL-D-LYSINE - Risk and Safety
N-EPSILON-T-BUTOXYCARBONYL-D-LYSINE - Introduction
H-D-Lys(Boc)-OH(H-D-Lys(Boc)-OH) is an organic compound that has the following properties and uses:
Nature:
-Appearance: Colorless or white crystalline powder
-Molecular formula: C17H31N3O5
-Molecular weight: 369.44g/mol
-Melting point: About 150-155 ° C
-Solubility: Soluble in acetic acid, dimethylformamide and formamide, slightly soluble in chloroform, almost insoluble in water
Use:
-Chemical synthesis: H-D-Lys(Boc)-OH is one of the commonly used protective amino acids in peptide chemical synthesis. It can protect the amino group on the amino acid side chain by replacing the hydroxyl group on D-lysine, thus preventing it from non-specific reaction with other reagents to ensure the selectivity of the target peptide in the synthesis process.
-Drug research and development: H-D-Lys(Boc)-OH is also widely used in drug research and development, such as as a protective agent in the synthesis of peptide drugs, the stability and biological activity of the drug can be increased.
Method:
The preparation of H-D-Lys(Boc)-OH is usually carried out by the following steps:
1. D-Lysine is dissolved in alcohol or other suitable solvent.
2. Add t-butyl carbamate (Boc2O) or other suitable acylating reagent to react with D-lysine.
3. After the reaction, the reaction mixture is acidified to remove unreacted reagents and intermediate products.
4. Purify the target product by crystallization or other methods.
Safety Information:
H-D-Lys(Boc)-OH is an organic compound, you need to pay attention to the following safety matters:
-avoid direct contact with skin and eyes, if accidentally contact, should immediately rinse with plenty of water.
-Wear appropriate personal protective equipment such as protective gloves, safety glasses and lab coat during operation.
-Operate in a well-ventilated laboratory to avoid inhaling its volatile products.
-Store away from fire sources and avoid contact with oxidants.
-Please read and follow the relevant safety instructions and operating procedures before use.
Last Update:2024-04-09 19:05:49